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Charleston, SC 5+ Bedroom Vacation Rentals

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162 rentals found
8BR - Beautiful CHS Home | Great for Gro...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 8 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
New design & construction, 6 Bed, 6 EnSu...

Welcome to 183 Saint Philip Street, your chic haven in the heart of Charleston! This new construction offers a prime location, placing you steps away from the city's vibrant attractions & best eateries. Each bedroom features 55" Samsung TVs ...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Hot Tub • Rooftop • Parking • Walk...

Summary:Welcome to Camellias on Cannon!☀️ Private Rooftop + Courtyard & Hot Tub???? 3 Blocks to King St – Walk to Charleston’s Finest Dining, Shopping & Nightlife???? Ideal for Substantial Groups – Families, Weddings, & Work Retreats???...

  • Charleston
  • 8 Bedrooms
  • 7 Bathrooms
  • Sleeps 16
The Cannon Exchange Building By Charlest...

Feel the pinnacle of Charleston living at the Cannon Exchange Building, a thoughtfully designed luxury property offering two broad residences: The Chateau and The Soirée. Each unit accommodates up to 14 guests, making the building ideal for huge...

  • Charleston
  • 10 Bedrooms
  • 10 Bathrooms
  • Sleeps 28
Brand NEW! 5BR/5BA Home, Perfect for Gro...

26 Bee Street features two distinct units in Charleston's beautiful Cannonborough/Elliotborough neighborhood. This vibrant property includes five bedrooms and five bathrooms across both units, each handsomely restored to showcase historic appeal...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
Guesthouse Charleston: Historic downtown...

Two elegant adjoining apartments offering a total of 5 bedrooms, 5 bathrooms, 2 full kitchens, and 2 roomy living rooms, making them ideal for bigger groups or families seeking both space and comfort. Located just one block from King Street in...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
The Edisto River Complex- 4 Condo Comple...

The PERFECT vacation rental for Weddings, Substantial Groups and Families looking to travel in complete opulent comfort and privacy! This 4 Condo- 8 Bedroom/ 8 Bathroom Complex is the ONLY property in Charleston that can host your entire event in...

  • Charleston
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 24
Gorgeous 6bd, 6ba Home, Made for Large G...

Summary:Welcome to your Charleston getaway, two standalone homes side-by-side, designed for groups who want space, comfort, and effortless appeal. Set in the heart of the city, you’ll be just steps from Charleston’s best dining, shopping, and...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Explore Downtown King St - 12 Bedrooms/7...

Summary:Welcome to your Charleston showcase, a enormous 12-bedroom, 7.5-bath estate located right in the heart of downtown just off King Street. Designed for huge groups, corporate retreats, or family gatherings, this property blends scale, style...

  • Charleston
  • 12 Bedrooms
  • 7 Bathrooms
  • Sleeps 16
Downtown Duplex - Coming St - Sleeps 20

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
4 Blocks to King! | The Dream Weaver

Permit Number: 06052The Space: Two full apartments. Six bedrooms. Four baths. One seamless stay.This completely refreshed three-story Charleston home is ideal for enormous groups who want space to spread out without sacrificing style. Bright...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Family and Pet-Friendly Retreat, 5BR Nea...

This property is new to Vacation Rental By Owner but we are well established hosts with our other property on vrbo and @irbnb with super host status and many reviews.Welcome to your home away from home! Our cavernous 5-bedroom, 3-bath home is ideal...

  • Charleston
  • 5 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Downtown home 5BR & 7 Beds w/ Free Priva...

The Space:- 5 cavernous bedrooms, 4 full baths, 2 half baths- Sleeps up to 14 guests—ideal for families, bachelorettes, and groups- Formal dining room with seating for 10- Entirely supplied kitchen with modern appliances- Cozy breakfast nook for...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
High Society | Historic District Gem Nea...

Summary:Feel High Society in this chic 6-bedroom, 3-bath home in Charleston’s Historic District. Unwind on private balconies with city vistas and appreciate the rare perk of off-street parking for four. Just blocks from King Street and the...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Stunning 6-Bedroom Home with Pool, 5.5 B...

More photos coming soon!Dive in to this newly remodeled 6-bedroom, 5.5 bathroom home with a brand new pool, ideal for hosting up to 12 guests. This three-story haven, adorned with wood floor, original fireplaces, and high ceilings with exposed...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
The Palmetto State Complex- 4 Condo Comp...

The PERFECT vacation rental for Weddings, Sizable Groups and Families looking to travel in complete opulent comfort and privacy! This 4-suite unit is the ONLY property in Charleston that can host your entire event in their own private suites just...

  • Charleston
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 24
Downtown Duplex - St Philip St

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 16
Professionally Designed 5bd Retreat, Ste...

Summary:Welcome to Emerson Square, a grandiose professionally designed getaway of a delightfully restored historic building, this broad five-bedroom residence is ideal for families and sizable groups. Appreciate a chef’s kitchen, SMART TVs...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 15