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Charleston, SC 5+ Bedroom Vacation Rentals

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162 rentals found
East 42 A & B - Entire Ground Floor, 2 U...

East 42 A & B is the combined listing for the two homes below. These two gorgeous homes can be connected via the fire door in the hallway creating a impressive five bedroom, five bathroom, with a queen murphy bed for flex linens, and two private...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
The Inns | 5 King Bed, 5 Bath | Spacious...

Summary:Feel true Charleston appeal at this collection of The Inns, an extravagant 5-bedroom, 5-bath Victorian getaway on Spring Street. Each room features a opulent king bed, while modern updates blend seamlessly with timeless Southern style...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Poolside Paradise Getaway - North Charle...

Summary:Feel a relaxing and fresh getaway in our handsomely appointed five-bedroom, three-bathroom single-family home in North Charleston. Designed with discerning guests in mind, this property offers modern amenities and refined conveniences...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
The King Suites at 493 - 8 Suites, 16 Be...

Permit Number: 004141The Space: Welcome to 493 Luxury Suites! These charmingly appointed units are found on the second floor of a historic building on King Street (above Sewing Down South, as seen on “Southern Charm”).Step into the building...

  • Charleston
  • 16 Bedrooms
  • 16 Bathrooms
  • Sleeps 52
The Manor 93 A&B - 2 Newly Renovated Uni...

Welcome to 93 Spring Street, a gorgeously restored 1880's Charleston home that combines historic appeal with modern amenities. Located just two and a half blocks from King Street, this cavernous home has been thoughtfully divided into two separate...

  • Charleston
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 14
Downtown Charleston 8 Bedroom

Freshly constructed, three-home complex, centrally located in Downtown Charleston! ✦Over 5,000 SQ FT!! ✦ Great for sizable groups - spend time together, but everybody can have their space!✦Open-air porches, welcoming living areas & cavernous...

  • Charleston
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 20
Casa Bella - Your Oasis in the Heart of ...

Permit Number: 05934The Space: Introducing Casa Bella: A Charming Charleston Retreat with Ample Space and Serene YardLocated in the heart of Charleston, Casa Bella offers a freshly-refreshed haven boasting 6 bedrooms, 4 bathrooms, and divided into 2...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Quarters on Spring-Rare CHS Retreat for ...

Welcome to The Quarters on Spring, an exceptionally roomy and elegantly refreshed Charleston hideaway located just mins. from the heart of downtown. It is rare to find a home this huge, this updated, and this appealing in such a prime location...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
5BR Rooftop Home with Parking Near King ...

Summary:Discover 'The Palmetto,' a impressive 5-bed, 5.5-bath Charleston getaway. This remodeled home spans three floors, featuring a detached guesthouse and a private rooftop terrace with city vistas. Ideal for sizable groups, it's just a 3-block...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Athena | Rooftop Patio | Short Walk to K...

Permit Number: 06283The Space: After February 2026, appreciate a brand-new extravagant pool in the enclosed backyard. Photos coming soon!Feel downtown living at its best in this gorgeous 3-story home. 'Athena' is ideal for huge groups and families...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
The Queen on King Street 7 Bedroom Duple...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 7 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Guesthouse Charleston: WEST (62 & 64)

West 62 and 64 are two beautiful homes located next door to each other, sharing a cavernous outdoor courtyard ideal for calming with drinks after a day of exploring Charleston. Each home offers generous living spaces, huge bedrooms, and multiple...

  • Charleston
  • 8 Bedrooms
  • 9 Bathrooms
  • Sleeps 24
Modernized 5BR Family Home?Tranquil Pati...

This handsome 5-bedroom, 2.5-bathroom home is a true gem, located on one of the quietest streets in Charleston. With freshly modernized bathrooms, resurfaced floors, and a roomy, open floor plan, this home is ideal for families or professionals...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
2 Luxury Houses w/ Patios | 1 Block from...

Summary:Discover luxury pair of completely modernized luxury homes ideal for a enormous group, located next door to each other just moments from King St. Indulge in chic interiors awash with natural light from wrap-around windows. These Charleston...

  • Charleston
  • 8 Bedrooms
  • 7 Bathrooms
  • Sleeps 20
Luxe 5BR w/ Heated Pool~1 Block to King~...

Welcome to The Lowcountry House, a handsomely restored 5-bedroom luxury getaway in the heart of Downtown Charleston with a Private Heated Pool. Originally constructed in the 1860s, this home exudes Lowcountry appeal with handcrafted details and...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
The Edisto River Complex- 4 Condo Comple...

The PERFECT vacation rental for Weddings, Extensive Groups and Families looking to travel in complete opulent comfort and privacy! This 4 Condo- 8 Bedroom/ 8 Bathroom Complex is the ONLY property in Charleston that can host your entire event in...

  • Charleston
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 24
Private Quartiers in Downtown Charleston

Summary:The Quartiers Charlestonian are a blend of historic appeal and modern luxury featuring five bedrooms and three baths in which were thoughtfully refreshed. These adjoining historic suites provide a private stay, just steps away from the...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Casa Zoë | Royal House – Charleston...

Summary:OP2025-06816OP2025-06817The Royal House is Charleston’s ultimate group escape: a dual-unit Casa Zoë mansion that blends grandeur, design, and independence. With 8 bedrooms, 8 baths, and separate living quarters, it offers shared elegance...

  • Charleston
  • 8 Bedrooms
  • 10 Bathrooms
  • Sleeps 16