Charleston-SC.com logo

Charleston, SC 5+ Bedroom Vacation Rentals

Filter 5+ Bedroom Charleston Properties by: Company | Pet-Friendly | or choose different a Area or Bedrooms
No company options available.
Bedrooms:
160 rentals found
Brand NEW! 5BR/5BA Home, Perfect for Gro...

26 Bee Street features two distinct units in Charleston's charming Cannonborough/Elliotborough neighborhood. This vibrant property includes five bedrooms and five bathrooms across both units, each elegantly restored to showcase historic appeal...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
19 Bedrooms in CHS | Private Pool! | The...

Permit Number: 06280The Space: Welcome to your ultimate group hideaway. This broad 4-unit, 19-bedroom property, with a *private pool* is thoughtfully designed for sizable groups, corporate retreats, wedding events, or multi-family vacations...

  • Charleston
  • 19 Bedrooms
  • 15 Bathrooms
  • Sleeps 38
The Fish! Most Unique High-End Luxury Re...

$250 Beach gear credit included with all new reservations! *Applies to 3-21 nighttime stays only* BR 1: 1 King, BR 2: 1 King, BR 3: 1 King, BR 4:1 King, BR 5: 4 Twins; Sleeps 12, Private Pool, High-End Unique Home, Screen Porch, Gas grille, Folly...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Historic 5bd Downtown w. Porches

Summary:Welcome to your sizable Charleston Victorian getaway, a gorgeously modernized historic residence occupying the entire second and third floors of a classic home on striking Spring Street. Combining timeless architectural character with modern...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 13
THE DELPHINE Luxury Downtown Charleston ...

Welcome to your beautiful getaway in the heart of Downtown Charleston! Located in the handsome Cannonborough/Elliotborough District, this impressive home constructed in 2022 is just steps from King Street’s top eateries, stores, and nightlife...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
The Monroe | 5BR - Voted Best of Charles...

Summary:Stay at The Monroe on Spring, a entirely modernized 1885 Charleston manor voted Finest of Charleston. Blending historic grandeur with modern luxury, this 5-bedroom getaway features chic interiors and sprawling porches ideal for calming after...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 16
The Queen on King Street 7 Bedroom Duple...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 7 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
8 Bedroom - Close to King Street - with ...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 8 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
6 Bedrooms! One Block to King Street!

Summary:Welcome to your Charleston gathering home, a six-bedroom property just one block from King Street that offers space, character, and plenty of outdoor appeal. Ideal for sizable families or groups who want walk-ability, historic details, and...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Rosemary House | Unit C | Sleeps 10

Summary:Welcome to the Rosemary House-Suite C at The Preserve, a cavernous and elegantly appointed residence occupying the upper floors of a delightfully preserved historic home. With 5 bedrooms and 5 bathrooms, this property offers ample privacy...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
Spacious 5BR Home sleeps 14- Families, B...

Welcome to The Penny Palace: Where History Meets Modern Comfort!This 3-story historic gem, is located in the heart of the Historical District in downtown Charleston and invites you to experience the timeless appeal of the 1800s with all the...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Pool! | 2 Blocks to King St | Parthenon ...

Permit Number: 05086The Space: Two homes. Ten bedrooms. Walk to King Street.This broad Charleston getaway is designed for sizable groups who want space to gather without sacrificing privacy. Tucked on a peaceful street just a 6-min. walk to King...

  • Charleston
  • 10 Bedrooms
  • 6 Bathrooms
  • Sleeps 20
The Inns | Grand 9BR Charleston Downtown...

Summary:Welcome to your Charleston gathering place where space meets luxury. This grandiose 9 bedroom home is constructed for sizable groups, offering eight full bathrooms to make everybody’s stay comfortable and convenient. Ideal for family...

  • Charleston
  • 9 Bedrooms
  • 8 Bathrooms
  • Sleeps 16
Charleston Villa | 6bd, Designer Downtow...

Summary:Welcome to your Charleston escape where roomy living meets beautiful design. This six bedroom home is ideal for enormous groups or families looking for comfort, modern amenities, and an inviting patio for gathering. You will savor privacy...

  • Charleston
  • 6 Bedrooms
  • 3 Bathrooms
  • Sleeps 16
Crosstown @ King | Elegant & Modern 6BR ...

Summary:Feel Charleston in style at this 6BR, 4BA Crosstown getaway just one block from King Street. Designed for up to 14 guests, the home combines modern finishes with cavernous comfort. Appreciate multiple living areas, a completely equipped...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Patio • Porches • Parking • Walk t...

Summary:✨ Welcome to Azaleas on Spring! ???????? 2.5 Blocks to King St! Walk to Charleston’s Finest Dining, Shopping & Nightlife???? Ideal for Grand Groups – Families, Wedding Guests, Bachelor(ettes) & Work Retreats???? Multiple Outdoor Spaces...

  • Charleston
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 18
Casa Zoë: Bright Charleston Cottage Nea...

Summary:OP2026-07256OP2026-07257Point of View Cottage is a bright and airy Casa Zoë getaway made from two seamlessly connected spaces - ideal for families, friends, or groups who want to stay together but still appreciate a bit of breathing room...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Largest Private Pool Downtown | Mint Jul...

Permit Number: 06995The Space: Step into a world of opulence and relaxation at The Mint Julep House, where every detail has been meticulously curated for an extraordinary stay. This two-story residence, freshly modernized and impeccably furnished...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12