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Charleston, SC 2+ Bedroom Vacation Rentals

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1050 rentals found
Downtown Duplex - Spring St

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 26
Private Backyard With Fire Pit, 15 Min t...

Welcome to this freshly modernized guesthouse in the heart of West Ashley. While staying in this adorable 850 sqft. home, you`ll fall in adore with the freshly redone kitchen featuring a comfortable breakfast nook. You`ll also savor: Deck with...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 4
Luxury Rooftop Penthouse - King Street!

Summary:Welcome to your Charleston skyline haven, a luxe rooftop penthouse perched above King Street where style meets serenity. Ideal for couples or modest groups who want sophisticated living, city energy, and memorable vistas, all in one...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Third Floor Private Sundeck! | The Posei...

Permit Number: 06282The Space: Welcome to The Poseidon — a roomy downtown getaway just off Spring Street. With 5 bedrooms, 3.5 baths, and an open layout constructed for gathering, it’s an ideal setup for families and bigger groups.Cozy. Central...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Hot Tub • Private Courtyard • 1 Bloc...

Summary:Welcome to The Palms of Charleston!☀️ Roomy Private Courtyard with Hot Tub???? 1 Block to King St! Walk to Charleston’s Finest Dining, Shopping & Nightlife???? Ideal for Substantial Groups – Families, Weddings, & Work Retreats???...

  • Charleston
  • 7 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Southern Cottage Tucked Under the Oaks

Pull into the established neighborhood Riverland Terrace, pass the boat ramp on Wappoo creek and you will find your Southern Cottage tucked under majestic Oak trees. This ranch style home has 3 bedrooms and 2.5 baths. The interior has newly been...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 9
The Juliette - Historic Luxury Residence

As featured in Vogue.Named as Charleston’s most design-forward Airbnb.Our upstairs flat suitably located in the heart of Downtown Charleston, it is our honor to introduce The Juliette. Prioritizing an opulent aesthetic with comfort in mind, it is...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
2BR Two Couples Suite | Dual Ensuite Bat...

Summary:Live like a local in this show-stopping two queen bedroom, two bath apartment located in downtown Charleston. Housed in The Charlestonian on the second floor, this suite offers private entrance, patio and porch, kitchen, living area...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 4
Downtown Family-Friendly Home By Restaur...

Summary:Flora House occupies the top floor of a majestic Historic Charleston residence dating back to 1905. While thoughtfully modernized for modern living, it delightfully preserves the appeal of its origins, featuring original wood floors and...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Stylish 2BR: Pet Friendly in Walkable Re...

Summary:Bowen VillageThe Space:Welcome to your fresh 2-bedroom, 2-bath guest suite located in the heart of the vibrant, walkable village of Bowen! Appreciate the ideal blend of luxury and convenience, just steps away from an array of trendy shopping...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 4
The Helène House - Spacious 4BD, 4.5BA ...

Summary:Recently refreshed 4BR/4.5BA home in laid-back Cannonborough/Elliotborough, ideal for families or friends. Lady Helene, Unit B features 4 ensuite bedrooms, open living/dining, a completely equipped kitchen, games room, private porch...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
In the Heart of King Street | Folly Suit...

Permit Number: 004141The Space: Welcome to your second-floor getaway in a delightfully restored historic building at iconic 493 King Street—right above Sewing Down South, featured on Southern Charm. Step outside and you’re instantly immersed in...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Pet-Friendly Charleston Home Near Dtwn!

Escape to this beautiful 3-bedroom, 2-bath vacation rental in Charleston. Ideally located, this home puts you within reach of Charleston's top attractions. Savor a walk through the historic downtown, dine at acclaimed eateries, or discover...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Remodeled 3bd, Marble Bathrooms, 150ft t...

Summary:Welcome to your chic downtown Charleston getaway, ideally located just steps from the acclaimed eateries, stores, nightlife, and historic appeal of Upper King Street. Occupying the entire second floor of a handsomely refreshed home, this...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 7
Casa Zoë | Elegant 3BR Retreat Near Kin...

Summary:OP2026-07256Palmetto Cottage is a signature Casa Zoë stay—effortlessly beautiful, light-filled, and ideally placed. With three ensuite bedrooms, open living spaces, and a attractively appointed kitchen, it’s designed for simple...

  • Charleston
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Hot Tub Oasis • Parking • 1 Block to...

Summary:Welcome to The Palms of Charleston – Suite A!☀️ Roomy Shared Courtyard + Hot Tub???? 1 Block to King St – Walk to Charleston’s Finest Dining, Shopping & Nightlife???? Private Porch???? Off-Site Parking for 1 Car????️ Cozy...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
19 Bedrooms in CHS | Private Pool! | The...

Permit Number: 06280The Space: Welcome to your ultimate group hideaway. This broad 4-unit, 19-bedroom property, with a *private pool* is thoughtfully designed for sizable groups, corporate retreats, wedding events, or multi-family vacations...

  • Charleston
  • 19 Bedrooms
  • 15 Bathrooms
  • Sleeps 38
Spacious James Island Retreat Near Beach

Charming James Island Retreat Near Folly BeachWelcome to your private James Island hideaway, ideally located between the sandy shores of Folly Beach and the historic appeal of downtown Charleston. Set on a roomy 1.3-acre property surrounded by...

  • Charleston
  • 3 Bedrooms
  • 1 Bathrooms
  • Sleeps 6