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Charleston, SC 2+ Bedroom Vacation Rentals

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1062 rentals found
Heart of Dwntwn Charleston+Full Kitchen+...

Modern Upper King St Home*Ideal for monthly stays * Free Wi-Fi and self-check-in* Free parking street parking available*driveway for one car*3 miles away from King street shopping stores * 8 miles to Tanger outlet* 11 miles to Charleston...

  • Charleston
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 6
The Longshoreman | Neighboring The Cedar...

Permit Number: 06165The Space: Welcome to The Longshoreman, your elegant Charleston getaway! This meticulously restored 1880s home offers a comfortable and cozy escape in the heart of the city.Curl up in one of the plush queen-size beds, adorned...

  • Charleston
  • 3 Bedrooms
  • 1 Bathrooms
  • Sleeps 6
The Fish! Most Unique High-End Luxury Re...

$250 Beach gear credit included with all new reservations! *Applies to 3-14 nighttime stays only* BR 1: 1 King, BR 2: 1 King, BR 3: 1 King, BR 4:1 King, BR 5: 4 Twins; Sleeps 12, Private Pool, High-End Unique Home, Screen Porch, Gas grille, Folly...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Beautiful Historic Charleston Home

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
? THE INNS ? Luxury 4BR Home Near King S...

Summary:Savor this handsomely designed 4BR/3BA first-floor suite just 4 blocks from King Street. Ideal for families or groups, this home features beautiful interiors, high-speed WiFi, Intelligent TVs, and a entirely equipped kitchen. With one...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
HEART of Downtown Overlooking Iconic Kin...

Summary:Welcome to your Charleston vantage point, where historic appeal meets elevated downtown living. Located directly above King Street, this home gives you sweeping city vistas, opulent interiors, and unmatched proximity to Charleston’s best...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Spring St - Downtown - Walk Everywhere!

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Guesthouse Charleston: SOUTH 82 B

Apartment with kitchen, 7-min. walk to Medical University of South CarolinaLaundry facilities and Bar-B-Que grilles are available at this smoke-complimentary apartment building. The apartment provides a kitchen with a refrigerator, an oven, a...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Across from MUSC. Perfect for interns mi...

Welcome to 40 Bee! We are located in the Cannonborough Elliottborough neighborhood of the downtown district across the street from MUSC, making this the prime location for students and medical professions. Whether you are traveling for business or...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 2
Boutique Luxury Apt Marion Sq Downtown |...

Spanning more than 700 square feet, this bright and well-appointed apartment offers a refined stay for families, couples, or business travelers alike.Two serene king bedrooms, each equipped with ceiling fans and sound machines, promise a restful...

  • Charleston
  • 2 Bedrooms
  • 1 Bathrooms
  • Sleeps 4
Casa Zoë | Grand Federal Sparrow House ...

Summary:OP2025-05862Sparrow House is a stately Federal-style, National Register residence reimagined for modern group stays. This full-home Casa Zoë gem blends historic appeal—porches, millwork, heart pine floors—with bold, gallery-worthy...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 13
The Manor 93 - B Beautiful Three Bed Thr...

The Manor 93 B is a charmingly designed 1880's Charleston home offering 3 en-suite bedrooms, an open living room, and a patio ideal for alfresco dining. Only 2.5 blocks to King St, with stores, eateries, and landmarks like the Battery and Market all...

  • Charleston
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 6
The Cannonball Suite | 1 Block to King S...

Permit Number: 05279The Space: Welcome to The Cannonball Suite! This charmingly modernized luxury home encompasses the entirety of a traditional Charleston Single home.Step off the private front porch into the colorful open floor plan kitchen and...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 4
Suite Retreat on Coming Street ~ Walk Ev...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
101 Mariners Cay! Luxury Living, Communi...

* BR 1: 1 King, BR 2: 1 Queen, BR 3: 2 Twins, Sleeps: 6Welcome to 101 Mariner's Cay! Appreciate a charming expansive view of the river and marsh from this 3 bedroom, 2 bathroom condo. Try your luck at fishing from the community dock, or go swimming...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Newly Renovated! Guesthouse Charleston: ...

Vacation home with a water park, 7-min. walk to Medical University of South CarolinaThis smoke-complimentary vacation home features a water park, laundry facilities, and Bar-B-Que grilles. The vacation home has 4 bedrooms and offers complimentary...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Walk to Charleston’s Best Dining and E...

One of four residences in this 1870s-era historic refreshed property, the 1,500-square-foot "Chestnut Suite" residence offers you a comfortable getaway. Blending the best of old and new, this historic home has been completely refurbished with modern...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 4
Island Retreat - Great for Large Groups

Summary:Conveniently located on James Island, 5 miles from Folly Beach and Downtown Charleston, this lush live oak property features 3 separate units that share a cavernous backyard. The individual units provide plenty of space for privacy with 1...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 14