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Isle of Palms, SC 5+ Bedroom Vacation Rentals

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127 rentals found
Brand New Custom Home~ Oceanfront, Pool,...

Step into unparalleled coastal luxury at this freshly constructed, professionally designed oceanfront 5-bedroom home—one of Isle of Palms' premier vacation units. Sandcastle, 2704 Palm Blvd., has every detail crafted for high-end living, from the...

  • Isle of Palms
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 10
9 24th Avenue by AvantStay | Walk to Bea...

Located at 9 24th Avenue, this gorgeously refreshed beach home offers six bedrooms, six full baths, and two half baths, making it the ideal getaway for enormous families and groups. Under new ownership, the home has undergone broad renovations and...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
4202 Palm Blvd.- 7 bedrooms, pool, putti...

**Ask about our current discounts!! *Plug in your dates to see the full quote! Email us (owner/property manager) with any questions regarding the home or the quote or discounts. --Description--This gorgeous rental property, Coastal Dreams, at 4202...

  • Isle of Palms
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Wonderful New Construction Home w/ Priva...

Check your cares at the door and settle into vacation mode at this beautiful Isle of Palms hideaway! Located just two blocks from the beach and only steps from the eateries and amenities of Wild Dunes Resort, this home really offers the best of both...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Steps to Isle of Palms Beach w/ Porch Di...

Welcome to Sea Haven by AvantStay!Just steps from the shimmering shores of Isle of Palms, Sea Haven is a bright, coastal escape designed for effortless beachside living. Located among swaying palms and serene island streets, this home offers the...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
IDEAL IOP Beach Home, 6 BR, Private Pool...

This charming 6 bedroom, 6.5 bathroom home is ready to welcome you for a once-in-a-lifetime beach escape. Just one block to the beach, it has all you need to make marvelous memories on the Isle of Palms. It features two living rooms, a completely...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Discounts! Beautifully decorated 206 Oce...

Ask about our Spring/Summer 2026 discounts! **This home books Friday to Friday in the Summer months**--Description--Part of our luxury collection, 'Villa Las Palmas', 206 Ocean Blvd., is a seven bedroom, seven and a half bathroom oceanfront home...

  • Isle of Palms
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Beautiful Ocean Views w/ Pool and Elevat...

2301 Palm BoulevardProperty Highlights- Enormous Private Pool - Can Be Heated - Across the Street from Beach Access Path- Rooftop Deck with Ocean Vistas- Elevator- $250 Beach Gear Credit with 3-14 nighttime stays!Please note that every reservation...

  • Isle of Palms
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
????Coastal Sunrise????Ocean Front on Oc...

**We are Saturday to Saturday in the Summer, but we have a 3 nighttime min in the off-season**--Description--Part of our Luxury Collection, 'Coastal Sunrise', 702 Ocean Blvd. is a six bedroom, six and a half bathroom, entirely modernized (April...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 14
Award-Winning Resort Amenities | 5 Fishe...

Fishers Alley 5 by Wild Dunes6 Bedrooms | 6 Bathrooms | Sleeps 12 | Reserve________________________________________Welcome to Fishers Alley 5, a impressive getaway on Isle of Palms’ exclusive Wild Dunes Resort. Just a block and a half from the...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Private Pool + Rooftop Ocean Views

All Decked Out – Relaxed Coastal Luxury with Rooftop Ocean VistasWelcome to All Decked Out, a delightfully designed Isle of Palms getaway where laid-back coastal living, broad outdoor spaces, and elevated beach home comfort create the ideal...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Luxury Oceanfront- Private Pool, Hot Tub...

Choose luxury, convenience, and comfort when you look for a vacation rental at the pretty Isle of Palms. If you excited to appreciate this handsome beach destination with your adored ones, you can stay at our oceanfront home at 700 Ocean Blvd. This...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 14
Whispering Palms- The Perfect Beach Hous...

-- Description --As part of our Island Collection, 8 31st Ave is a striking beach home you won't forget. Located just one short block from the ocean, you can conveniently hop on the beach path at the end of the street. Savor spending beach time with...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Large Home Right by the Beach! Private P...

3205 Palm Boulevard Meet your new favorite vacation home, Atlantic Breezes on 3205 Palm Boulevard! This amazing 5-bedroom, 4.5-bathroom home is located just across Palm Boulevard from the beach, with a handsome private pool and play set in the...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Pool, Beach Access, Walk to Town, Pet ok...

Make everlasting memories with you and your whole family on your next vacation at 808 Ocean Boulevard. 808 Ocean Boulevard is a impressive private 6 bedroom 6 bath home located oceanfront on the southern side of the Isle of Palms. Just mins. walk...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 14
8 bedroom LUXURY IOP Home with Private P...

Welcome to 3907 Palm Boulevard, a gorgeous 8-bedroom ocean view home on the impressive Isle of Palms, just a short drive from the historic city of Charleston. This freshly constructed residence showcases refined coastal elegance throughout, offering...

  • Isle of Palms
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 12
311 Carolina by AvantStay | Rooftop Ocea...

311 Carolina Boulevard is really a rare find with ocean vistas, private pool, four cavernous decks, and magnificant amenities to meet your every vacation wish. Step into your vacation dream that features five bedrooms, each with a king bed, four...

  • Isle of Palms
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
New Listing! Ask about discounts! 3900 P...

New to our luxury collection, 3900 Palm Blvd. is a striking five bedroom oceanfront home. Welcome to your dream vacation home on the pristine shores of Isle of Palms, South Carolina. This impressive five bedroom, four full bathrooms and two half...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12