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Isle of Palms, SC 5+ Bedroom Vacation Rentals

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120 rentals found
Southern Oasis by AvantStay | 0.5mi Walk...

Welcome to Southern Oasis, your dream hideaway on the beachy Isle of Palms! Just 30 mins. from downtown Charleston, Southern Oasis is ideal for those seeking a calming getaway located just outside of the city’s excitement.Brimming with southern...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
STUNNING Oceanfront Home! Golf & Ocean V...

Are you searching for an memorable luxury escape for your family? You'll be sure to find it here at Ocean Point. Overlooking both the Atlantic Ocean and the 17th Fairway of the Links Golf Course, this sprawling home offers six bedrooms and over five...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Hot tub, Private Pool, Pet Friendly, Sun...

Brand New Hot Tub just added! Appreciate the vistas of Hamlin Creek, the Intracoastal Waterway, and the handsome sunsets seen from the second story wrap around deck of Palmetto Sunset. It is a five-bedroom, three-bathroom home directly across from...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
Casa Banana Oceanfront on Ocean Blvd, 6 ...

Welcome to Casa Banana! Presented by Exclusive Properties on Isle of Palms. *Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. NOTE: Prices include linens and cleaning!**Available...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 20
Discounts! Sea Spray- 400 Ocean Blvd. Oc...

Ask about our discounts for Spring/Summer 2026!Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 15
1 block to beach! 500 Carolina Blvd. 5 b...

Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in charming, luxury or budget friendly vacation...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
3108 Palm by AvantStay | Oceanfront, Pri...

Welcome to 3108 Palm by AvantStay!Welcome to 3108 Palm, your oceanfront sanctuary on the Isle of Palms. This beach villa beckons with a private boardwalk leading you directly to the shore, ensuring countless moments of oceanside bliss.Dip into...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Walk to the Beach + Private Pool, Roofto...

Welcome to 3602 Cameron, where beachside living meets modern elegance. Located in the heart of the Isle of Palms, this gorgeous getaway is just steps from pristine sandy shores, offering the ideal blend of relaxation and convenience. Whether you're...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
New Listing! Ask about discounts! 3900 P...

New to our luxury collection, 3900 Palm Blvd. is a impressive five bedroom oceanfront home. Welcome to your dream vacation home on the pristine shores of Isle of Palms, South Carolina. This lavish five bedroom, four full bathrooms and two half...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Luxurious 6bd Isle of Palms Home with PO...

WELCOMING RENTERS BEGINNING mid-MARCH 2026! --MORE PHOTOS COMING SOON--Welcome to your ideal Isle of Palms escape at 23 26th Avenue—a gorgeous home designed for effortless coastal living. Ideally located just one block from the Isle of Palms...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Abalone Alley 04 - Easy Breezy  - Privat...

4 Abalone Alley- Simple BreezyIsle of PalmsRecently Available with Dunes Properties. Overview:Welcome to Painless Breezy. The name says it all! This completely refreshed 5 bedroom and 4 bath home has top notch finishes in the brand new baths and...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Oceanfront Grand Pavilion- 5 bedrooms! V...

This striking, oceanfront 5 bedroom home in the Grandiose Pavilion community at Wild Dunes Resort is just what you've been searching for! The home is refreshed, you'll find new appliances, updated floor, and brand new furnishings throughout! But...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
913 Carolina Boulevard by AvantStay | Pr...

Come drop your anchor on the Isle of Palms for your next family vacation at 913 Carolina Boulevard! This seven-bedroom home is the ideal place to relax and relax with fabulous amenities, simple beach access, and a private swimming pool constructed...

  • Isle of Palms
  • 7 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
AMAZING Golf and Ocean View Home! Privat...

Step inside 37 Ocean Point. A luxury five bedroom, five bathroom home in the Ocean Point neighborhood of the Wild Dunes community. Located at the very end of Wild Dunes, Ocean Point is highly sought-after due to its privacy, impressive and broad...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
IOP Luxury House With Private Pool, 6 Be...

Only a brief walk from the pristine sandy beach, this impressive 6-bedroom, 4.5-bathroom coastal getaway offers the ideal blend of relaxation, style, and convenience. Designed with families and groups in mind, this Isle of Palms vacation home is...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Discounts!! Serenity- 2 50th One of a ki...

Ask about our Summer 2026 discounts!! *During Summer months this home books Friday to Friday**Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote. --Description--New to our Luxury Collection...

  • Isle of Palms
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
712 Ocean Blvd | New Build + Pool, Game ...

Sun, sand, and wellness collide at Stay Salty—a brand-new, oceanfront getaway on Isle of Palms where modern luxury meets intentional, healthy living. With six bedrooms (including 5 California King beds), six full bathrooms, and a powder room, this...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Villa Del Mare PRIVATE POOL/HOT TUB, OCE...

** During the summer we book Saturday to Saturday. Off-season we require a 3 nighttime minimum **-- Description --'Villa del Mare' is an ocean view Mediterranean masterpiece and is located just a few steps from the beach. On the calming Isle of...

  • Isle of Palms
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 20