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Isle of Palms, SC 5+ Bedroom Vacation Rentals

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131 rentals found
Waterway Views, Private Pool, Hot Tub, I...

Welcome to SEA'S THE DREAM! Just north of historic Charleston sits this appealing 5 bedroom home with private pool and vistas of the spectacular Intracoastal Waterway on the Isle of Palms. It would surely be the ideal spot for your next vacation! ...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
1blck to Beach, Pool, Outdoor Kitchen, G...

Welcome to Pelican, an AvantStay home!Just a block from the famed Island of Palms Beach, this beautiful, modern getaway is the ideal spot for your next coastal hideaway. An impressive outdoor space presents a taste of heaven, where days are spent...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
2910 Palm Blvd- New Oceanfront Luxury- P...

**Ask about our current discounts!! Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in impressive...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
9 24th Avenue by AvantStay | Walk to Bea...

Located at #9 on 24th Avenue, this beach home features six bedrooms, six full baths, and two half baths. A beach path at the end of the block makes walking to the surf simple for the entire family, where they will find one of the best stretches of...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Walk to the Beach + Private Pool + Rooft...

Tucked into the peaceful north end of Isle of Palms, 3602 Cameron is the kind of beach home that makes you slow down the second you walk in. The ocean is essentially across the street — Beach Access 34A sits just steps from the front door, so...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
311 Carolina by AvantStay | Rooftop Ocea...

311 Carolina Boulevard is really a rare find with ocean vistas, private pool, four cavernous decks, and amazing amenities to meet your every vacation wish. Step into your vacation dream that features five bedrooms, each with a king bed, four full...

  • Isle of Palms
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Historic Home near the Beach w/ Pool | 3...

Welcome to 306 Charleston Roosevelt Retreat by AvantStay, a rare Isle of Palms gem where coastal ease meets rich American history. Constructed in 1958 by Nicholas G. Roosevelt—a cousin of Franklin D. Roosevelt and a direct descendant of the...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Updated Wild Dunes 5BD Steps from Beach-...

Ever wonder what a true resort beach vacation near Charleston would be like? Then it's time to experience "LIVIN' ON A DUNE"!Located in the heart of Wild Dunes Resort on the Isle of Palms and just a block away from the pristine beach, this...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Stunning Home! Pool, Theater Room, Steps...

$200 Gift Card Special for WEEK stays!Qualifying weeks are - June 27th - July 11th. Amazing luxury rental located on a peaceful street just a few steps to the beach boardwalk. Loaded with outdoor amenities including an broad backyard complete...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 11
Villa Del Mare PRIVATE POOL/HOT TUB, OCE...

** During the summer we book Saturday to Saturday. Off-season we require a 3 nighttime minimum **-- Description --'Villa del Mare' is an ocean view Mediterranean masterpiece and is located just a few steps from the beach. On the relaxing Isle of...

  • Isle of Palms
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 20
Oasis w/ Private Pool, Pets considered, ...

Welcome to your hideaway getaway at The Pink House! 5 Bedroom, 3 Bathroom home with all new refreshed bathrooms as of 2023, a 50ft long private pool, and less than a 2 min. walk to the beach. The pool has two 6 in wading areas that is great for...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Cozy Family Beach Home w/Private Pool & ...

Get ready for an impressive and fun-filled beach vacation when you select charming accommodation for your stay. At Carroll Realty, we are excited to tell you about this roomy vacation home located right by the ocean. Walk a few steps to savor the...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 13
AMAZING Golf and Ocean View Home! Privat...

Step inside 37 Ocean Point. A luxury five bedroom, five bathroom home in the Ocean Point neighborhood of the Wild Dunes community. Located at the very end of Wild Dunes, Ocean Point is highly sought-after due to its privacy, striking and broad...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
Spacious Coastal Home with Private Pool ...

Book June 13-20, 2026 and receive a complimentary golf cart rental for the week! BR 1: King, BR 2: King, BR 3: King BR 4: King, BR 5: King, BR 6: King, BR 7: King, BR 8: 2 Queens, BR 9: 2 Twin, BR 10: 2 Twin; Sleeps 22, Near Beach, Private Pool...

  • Isle of Palms
  • 10 Bedrooms
  • 7 Bathrooms
  • Sleeps 22
3100 Palm Boulevard by AvantStay | Beach...

3100 Palm Boulevard, "One Summer Dream"Many great novels of the South focus on the South Carolina Low Country and its marvelous beaches, spawning dreams of life on its idyllic coast. These images can be your reality when you plan your next...

  • Isle of Palms
  • 7 Bedrooms
  • 8 Bathrooms
  • Sleeps 12
Saltwater Sanctuary | Ocean Views + Priv...

The Delaney House – Relaxed Coastal Luxury on Isle of PalmsWelcome to The Delaney House, a elegantly refreshed Isle of Palms getaway where ocean vistas, casual coastal interiors, and a private saltwater pool create the ideal backdrop for an...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Discounts! OCEANFRONT STUNNER- Discounte...

**Ask about our current discounts for Spring/Summer 2026!Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We...

  • Isle of Palms
  • 7 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Casa Flamingo Oceanfront Dreamhouse! 8 b...

Welcome to Casa Flamingo! Presented by Exclusive Properties on Isle of Palms. *Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. **Available all year! During the Summer months...

  • Isle of Palms
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 18