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Isle of Palms, SC 5+ Bedroom Vacation Rentals

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286 rentals found
Guesthouse Charleston: SOUTH 105 A & B

Located peacefully on coveted Spring Street, this impressive standalone duplex features eight cavernous bedrooms and eight full bathrooms, just steps away from Cannon Green and just three blocks to historic King Street. Ideal for enormous groups or...

  • Charleston
  • 8 Bedrooms
  • 9 Bathrooms
  • Sleeps 20
All Decked Out on Sullivans Island

This fantastic home is difficult to describe in words so please check out the video after the second picture of the slide show of photos at the top of the page. Spectacular ocean vistas from every bedroom as well as outdoor hot tub and private pool...

  • Sullivans Island
  • 6 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
2 Luxury Houses w/ Patios | 1 Block from...

Summary:Discover luxury pair of completely remodeled luxury homes ideal for a sizable group, located next door to each other just moments from King St. Indulge in modren interiors awash with natural light from wrap-around windows. These Charleston...

  • Charleston
  • 8 Bedrooms
  • 7 Bathrooms
  • Sleeps 20
Thomas Waring House | Sleeps 23 | Multi-...

Summary:Welcome to the Thomas Waring House at The Preserve, a historic and award-winning residence that offers a unique blend of appeal and modern convenience. Comprising 4 separate units, this broad property features a total of 11 bedrooms and 11.5...

  • Charleston
  • 11 Bedrooms
  • 11 Bathrooms
  • Sleeps 23
????Casa Margarita???? ~Oceanfront, 10BD...

Welcome to Casa Margarita!**904 Ocean Blvd. Presented by Exclusive Properties Vacation Rental Agency on Isle of Palms***Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. NOTE: Prices...

  • Isle of Palms
  • 10 Bedrooms
  • 11 Bathrooms
  • Sleeps 22
Full Renovation of 1811 historical home....

Freshly restored and only 2 blocks from the heart of the entertainment district of Upper King Street, Stay Cannon is the ideal landing place for your next trip to Charleston.Stay Cannon is a legally allowed vacation rental as required by Charleston...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Charleston Villa | 6bd, Designer Downtow...

Summary:Welcome to your Charleston escape where cavernous living meets beautiful design. This six bedroom home is ideal for enormous groups or families looking for comfort, modern amenities, and an inviting patio for gathering. You will savor...

  • Charleston
  • 6 Bedrooms
  • 3 Bathrooms
  • Sleeps 16
Vacation Villa 5 mins to King St ‘The ...

Summary:Vacation Villa 5 min. walk to King St, in the heart of downtown Charleston. This tropical getaway offers sleek design, soaring 25’ ceilings, open first floor kitchen & living room, and cavernous bedrooms with en-suite spa bathrooms. The...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
The Queens Palace | 8 Bedrooms in Charle...

Permit Number: 05553The Space: The SpaceWelcome to The Queen’s Palace, your private Charleston getaway made up of three attractively restored historic homes in the heart of the Cannonborough-Elliotborough neighborhood. With 8 bedrooms, 8...

  • Charleston
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 16
6 36th Avenue by AvantStay | Stunning Pr...

Welcome to your dream coastal getaway! Located just steps away from the sandy shores, this freshly modernized five-bedroom, five-bathroom home is a masterpiece of luxury and comfort. The exterior is adorned with lush landscaping, creating a serene...

  • Isle of Palms
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 11
The Rose Charleston | Perfect for Large ...

Summary:Escape to The Rose, a gorgeously refreshed 2-story Charleston classic in the heart of downtown. With 6 bedrooms and 4 bathrooms, this modren getaway is ideal for enormous groups seeking both space and comfort. Unwind in the inviting living...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
Entire Home Rental in Downtown Charlesto...

Summary:Ideal for a enormous family! This home is divided into two apartments, A & B, and this listing is for the entire home. This home sleeps 16 guests total. Just three blocks away from upper King Street. Our magnificent cultural city also offers...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Guesthouse Charleston: SOUTH 105 ALL

This combined listing for South 105 A, B, & 105.5 is a great space for sizable groups. Each unit has 4 bedrooms, and 4.5 bathrooms totaling 12 bedrooms, 12 full bathrooms, 3 half bathrooms, 3 full kitchen/living areas. Located on the desired Spring...

  • Charleston
  • 12 Bedrooms
  • 13 Bathrooms
  • Sleeps 28
STEPS to King St - 6 Bedroom Home - Spac...

Summary:Welcome to your Charleston escape, a generously sized 6-bedroom home constructed for big groups who want to be in the heart of the action yet appreciate broad living spaces. Ideal for family get-togethers or friend get-togethers, this home...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
88 Grand Pavilion | AvantStay | Near Bea...

Appreciate a break from your hectic pace at 88 Grandiose Pavilion. Located on a cozy tree-lined street, this 5 bedroom, 4.5 bath home is a modern beach bungalow that is located in the heart of Wild Dunes. Finest yet, it is only a three-min. walk to...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
The Chapel | 8BR Charleston Charmer - Wa...

Summary:Welcome to The Chapel, a attractively restored 8-bedroom gem in Charleston where character, comfort and convenience come together. Ideal for enormous families or groups, this home offers cavernous common areas, extravagant design details and...

  • Charleston
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 16
CLASSIC and Cozy IOP Beach Home, Family-...

Great Family Friendly 5 bedroom home located on a corner lot. Only two blocks from the IOP marina and close to the beach. This home is boat friendly with painless access to the IOP Boat Ramp. You will appreciate how this home can accommodate a very...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
Discounts!! Serenity- 2 50th~ One of a k...

Ask about our Summer 2025 discounts!! *During Summer months this home books Friday to Friday**Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote. --Description--New to our Luxury Collection...

  • Isle of Palms
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12