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Isle of Palms, SC 5+ Bedroom Vacation Rentals

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128 rentals found
Ultra-Luxury Oceanfront Home | 58 Grand ...

NEW PHOTOS COMING SOON!!Introducing 58 Grandiose Pavilion, your unparalleled luxury escape in the heart of Wild Dunes. This elegant oceanfront getaway, entirely remodeled in 2023, offers 6 bedrooms and 6.5 bathrooms across 3,900 square feet of pure...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Updated Wild Dunes 5BD Steps from Beach-...

Ever wonder what a true resort beach vacation near Charleston would be like? Then it's time to experience "LIVIN' ON A DUNE"!Located in the heart of Wild Dunes Resort on the Isle of Palms and just a block away from the pristine beach, this...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
1 Block to Beach, Newly Renovated 6BDR w...

Welcome to Sand Dune. Heaven beckons from this marvelous beach home that's located only 1 block away from the sandy shores of Isle of Palms Beach. Recently refreshed in 2025, Sand Dune now features major upgrades to the kitchen and bathrooms...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Private Pool, Game Room with Ping Pong T...

Snowbirds Welcome!!Winter Escape to IOP.....Property Description Discover the pinnacle of luxury beach living at this exquisitely designed beach home, located in the heart of Isle of Palms, South Carolina. This impeccable getaway blends coastal...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Luxe Isle of Palms Retreat • Pool + Fi...

Sparrow Haus is what happens when laid-back beach living gets a serious luxury upgrade. This 5-bedroom, 5.5-bath Isle of Palms getaway is polished, private, and made for memorable group getaways, with high-end design throughout, soaring ceilings...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
311 Carolina by AvantStay | Rooftop Ocea...

311 Carolina Boulevard is really a rare find with ocean vistas, private pool, four roomy decks, and impressive amenities to meet your every vacation wish. Step into your vacation dream that features five bedrooms, each with a king bed, four full...

  • Isle of Palms
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Beachwood East 19 by Wild Dunes, Ocean V...

Beachwood East 19 by Wild Dunes7 Bedroom | 7 Bathroom | Sleeps 16 | Oceanfront _____________________________________Welcome to Beachwood East 19, a impressive getaway on Isle of Palms’ exclusive Wild Dunes Resort. Feel island living in this...

  • Isle of Palms
  • 7 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
????'Dolphin Manor' ~ OCEAN FRONT, PRIVA...

** During the summer and holidays we book Saturday to Saturday. Off-season we require a 3 nighttime minimum **Description'Dolphin Manor' -512 Ocean Blvd, was completely refreshed Spring 2021 and is the ideal oceanfront home for your hideaway! With...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Coastal Manor~ 6 bdrm, across from ocean...

** During the summer we book Friday to Friday. Off-season we require a 3 nighttime minimum **--Description--'Coastal Manor' is a brand new bespoke constructed home located on Palm Blvd. right across from the ocean with a convenient beach access just...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Large Home Right by the Beach! Private P...

3205 Palm Boulevard Meet your new favorite vacation home, Atlantic Breezes on 3205 Palm Boulevard! This marvelous 5-bedroom, 4.5-bathroom home is located just across Palm Boulevard from the beach, with a beautiful private pool and play set in the...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Fairway Oaks 8 by Wild Dunes, With Ameni...

Fairway Oaks 8 by Wild Dunes5 Bedrooms | 4.5 Bathrooms | Sleeps 12 | Resort View________________________________________Fairway Oaks 8, a striking freshly modernized getaway on Isle of Palms’ exclusive Wild Dunes Resort. Where Lowcountry appeal...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Seascapes 714 Ocean Blvd. Charming, Ocea...

**We are Saturday to Saturday in the Summer, but we have a 3 nighttime min in the off-season**--Description--'Seascapes' 714 Ocean Blvd, is a classic oceanfront home located in the esteemed Ocean Blvd. side of the island which places the beach just...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Escape to Global Elegance: A Coastal San...

Escape to Global Elegance: A Coastal Sanctuary at 6 31st Avenue!Property HighlightsGrand Private Pool A few mins. walk to the beachChefs KitchenElevator$250 Beach Gear Credit with 3-14 nighttime stays!Note- All TVs are streaming only so please bring...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 16
2 Condos in Wild Dunes, Pool + Hot Tub, ...

Welcome to 401 Yacht & 405 Yacht by AvantStay! These two condos are located in the Yacht Harbor Condominiums with a combined total of 5 bedrooms, sleeping 12 guests—an ideal option for family trips or groups looking to spread out.Yacht Harbor...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Beach Access Directly Across Street! Oce...

Brand New Construction! Ocean Thriller at 903 Ocean Boulevard on the Isle of Palms is a Ocean view, 6 bedroom, 6 ensuite, and 2 half bath, bespoke-constructed home as of 2024. Located in a premier spot with the beach just across the street. Savor...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
1blck to Beach, Pool, Outdoor Kitchen, G...

Welcome to Pelican, an AvantStay home!Just a block from the famed Island of Palms Beach, this striking, modern getaway is the ideal spot for your next coastal hideaway. An amazing outdoor space presents a taste of heaven, where days are spent...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Brand New Luxury 6 bedrooms, 7.5 bathroo...

Nostos~ 6 51st Ave presented by Exclusive Properties on Isle of Palms. Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
3 47th Avenue by AvantStay | Oceanfront ...

Welcome to 3 47th Avenue, where impressive architecture meets modern design. This cavernous getaway invites you to indulge in the ideal blend of luxury and comfort.Marvel at the unique private pool, boasting an in-water sitting area for unparalleled...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12