Charleston-SC.com logo

Isle of Palms, SC 5+ Bedroom Vacation Rentals

Filter 5+ Bedroom Isle of Palms Properties by: Company | or choose different a Area or Bedrooms
No company options available.
Bedrooms:
124 rentals found
Discounts! Sea Spray- 400 Ocean Blvd.~ O...

Ask about our discounts for Summer 2025!Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in pretty...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 15
Steps to Beach, Private Pool, Spacious F...

Looking for the ideal Isle of Palms escape? You'll find it here at 3103 Palm Boulevard. This huge 4,100 square foot estate features a private saltwater pool, three levels, refreshed interiors, and is steps away from the sandy beaches of the Carolina...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Discounts! Beautifully decorated~ 206 Oc...
5.0
(5)

Ask about our Summer 2025 discounts! **This home books Friday to Friday in the Summer months**--Description--Part of our luxury collection, 'Villa Las Palmas', 206 Ocean Blvd., is a seven bedroom, seven and a half bathroom oceanfront home that was...

  • Isle of Palms
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Coastal Manor~ 6 bdrm, across from ocean...
4.9
(16)

** During the summer we book Friday to Friday. Off-season we require a 3 nighttime minimum **--Description--'Coastal Manor' is a brand new bespoke constructed home located on Palm Blvd. right across from the ocean with a convenient beach access just...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Hot tub, Private Pool, Pet Friendly, Sun...
4.2
(5)

Brand New Hot Tub just added! Appreciate the vistas of Hamlin Creek, the Intracoastal Waterway, and the pretty sunsets seen from the second story wrap around deck of Palmetto Sunset. It is a five-bedroom, three-bathroom home directly across from...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
Amazing IOP Vacation Home! 5 bedrooms wi...

NEW SWEETGRASS LISTING FOR 2025! Escape to this striking 5-bedroom, 4-bathroom beach home, ideally located just two blocks from the pristine Isle of Palms beach. Designed for relaxation and entertainment, this home features a private pool and hot...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
private pool steps to the beach

6 54th Ave | Blue HavenIsle of Palms, SCOverview:Welcome to "Blue Haven," a spectacular 5 bedroom and 5 ½ bath home with a pool and ocean vistas. This enormous home has 2 broad living rooms and each have access to a cavernous veranda with...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
4202 Palm Blvd.- 7 bedrooms, pool, putti...

**Ask about our current discounts!! *Plug in your dates to see the full quote! Email us (owner/property manager) with any questions regarding the home or the quote or discounts. --Description--This striking rental property, Coastal Dreams, at 4202...

  • Isle of Palms
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Second row back from the beach, cornhole...
4.6
(17)

One row back from the beach! This ocean view, 9 bedroom 6 and a half bath home is loaded with amenities for your family getaway. Charm and coastal style are found throughout this handsome vacation home which has an in ground pool, sizable yard with...

  • Isle of Palms
  • 9 Bedrooms
  • 6 Bathrooms
  • Sleeps 20
????1 block to beach! 500 Carolina Blvd....

Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in gorgeous, luxury or budget friendly vacation...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Sunset Point - Stunning Luxury
4.3
(4)

This oceanfront, bespoke constructed 6 bedroom/8.5 bathroom home features 7,000 square feet of pure elegance. Each room was professionally designed and no expense was spared. The attention to detail includes stone floor throughout the first floor...

  • Isle of Palms
  • 6 Bedrooms
  • 8 Bathrooms
  • Sleeps 12
AMAZING Golf and Ocean View Home! Privat...
5.0
(5)

Step inside 37 Ocean Point. A luxury five bedroom, five bathroom home in the Ocean Point neighborhood of the Wild Dunes community. Located at the very end of Wild Dunes, Ocean Point is highly sought-after due to its privacy, striking and broad...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
Beautiful Ocean Views w/ Pool and Elevat...

2301 Palm BoulevardProperty Highlights- Grand Private Pool - Can Be Heated - Across the Street from Beach Access Path- Rooftop Deck with Ocean Vistas- Elevator- $250 Beach Gear Credit with 3-14 nighttime stays!Steps from the ocean, countless outdoor...

  • Isle of Palms
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
New Listing! Lagoon View, close to Beach...

Brand new to the rental program! Remodeled in 2024 with all rooms freshly painted, refinished wood floors throughout, and a new kitchen. Incredible 5 Bedroom vacation home in the exclusive gated Ocean Point Community of Wild Dunes Resort. Access to...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
????Brand New???? Custom Oceanfront home...

Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in handsome, luxury or budget friendly vacation...

  • Isle of Palms
  • 6 Bedrooms
  • 8 Bathrooms
  • Sleeps 12
????Casa Margarita???? ~Oceanfront, 10BD...
4.8
(11)

Welcome to Casa Margarita!**904 Ocean Blvd. Presented by Exclusive Properties Vacation Rental Agency on Isle of Palms***Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. NOTE: Prices...

  • Isle of Palms
  • 10 Bedrooms
  • 11 Bathrooms
  • Sleeps 22
Wonderful 5 BR Family Beach Home on Quie...
4.8
(5)

Welcome to a cavernous, extravagant, airy, and modern beach home at the handsome Isle of Palms. With five bedrooms and four bathrooms, this giant vacation rental is the ideal way to spend your holiday for your beach vacation. There is ample space...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Luxury, Oceanview Beach Home w/ Private ...
5.0
(2)

Vacation in style and live like royals when you book our roomy and opulent 609 Ocean Blvd beach home at Isle of Palms. Stay right opposite the ocean at one of the best spots in the area and spend a memorable time with your appreciated ones. At...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12