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Charleston, SC 4+ Bedroom Vacation Rentals

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358 rentals found
The Preserve | Barbados House | 5 BR + 5...

Summary:Welcome to the Barbados House, part of The Preserve, a luxury single-style home located in the heart of downtown Charleston. This gorgeous 5-bedroom, 5.5-bath residence offers an unparalleled blend of sophisticated appeal and modern comfort...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Belle Haven Duplex - Downtown - New Reno...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Large, Historic 6BR, Designed to Perfect...

Summary:Welcome to Palmetto Hideaway, a gorgeous 6-bedroom designer home in the heart of downtown Charleston. Ideal for sizable families, friend getaways, or anyone who craves style, space, and character, it immerses you in history while offering...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Chateau Charleston | Luxury Oasis w/ 3 N...

Summary:Welcome to Chateau Charleston, a opulent getaway comprised of three freshly constructed homes on a shared property, offering style, privacy, and resort-like amenities. Ideal for multiple families or groups traveling together, this compound...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
Screened Porch + Patio: Spacious Charles...

3,000 Sq Ft | Family-Friendly Conveniences | 3 Mi to Folly Beach | 10 Mi to DtwnMake this 5-bedroom, 3-bathroom vacation rental your home base as you discover all Charleston has to offer. The 'James Island Folly Family Retreat' includes multiple...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
New design & construction, 6 Bed, 6 EnSu...

Welcome to 183 Saint Philip Street, your chic haven in the heart of Charleston! This new construction offers a prime location, placing you steps away from the city's vibrant attractions & best eateries. Each bedroom features 55" Samsung TVs ...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Guesthouse Charleston: WEST (62)

At 62 West, you'll feel right at home during your Charleston visit—front porch included! In addition to comfortable beds, this home offers a roomy open-concept living room and kitchen, ideal for entertaining. The elegantly landscaped outdoor...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Spring St - Downtown Charleston - Walk E...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Guesthouse Charleston: SOUTH (105 ALL)

This combined listing for South 105 A, B, & 105.5 is a great space for sizable groups. Each unit has 4 bedrooms, and 4.5 bathrooms totalling 12 bedrooms, 12 full bathrooms, 3 half bathrooms, 3 full kitchen/living areas. Located on the desired Spring...

  • Charleston
  • 12 Bedrooms
  • 13 Bathrooms
  • Sleeps 28
Downtown Luxury 5 Bed + Elevator, Parkin...

Summary:Stay at The Charlee on Cannon, a brand-new 4BR, 3BA suite blending modern luxury with Charleston appeal. Savor a cavernous open-concept living area, private balcony, plenty of seating, and rare ADA accessibility with elevator access...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Sullivan & Palm | Downtown Oasis | Priva...

Summary:Walkable to four Michelin eateries with a saltwater pool out back, this 5BR downtown home is an painless base for a family trip or a group weekend. The fenced yard gives the kids somewhere to run while everybody else settles in poolside...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
Third Floor Private Sundeck! | The Posei...

Permit Number: OP2026-07350The Space: Welcome to The Poseidon — a roomy downtown getaway just off Spring Street. With 5 bedrooms, 3.5 baths, and an open layout constructed for gathering, it’s an ideal setup for families and bigger groups.Cozy...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Mint Julep Residence @ Smalls Alley w/ H...

Welcome to the Mint Julep Residence, the grandest home in the Smalls Alley collection of standalone luxury homes in downtown Charleston. Unlike its sister residences in the alley, this famed historic home sits at its own address, 129 Cannon Street...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Waterfront Private Retreat near Folly Be...

WELCOME TO MARSH MADNESSEscape to your own private corner of the Lowcountry at Marsh Madness, a cavernous waterfront getaway surrounded by sweeping marsh and river vistas. With a private pool, deepwater dock, wraparound porches and memorable...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Renovated 4BR Downtown w. Gym Access + P...

Summary:Freshly painted and upgraded with brand-new beds and linens, the home is filled with natural light and timeless Southern character. Appreciate coffee or a home-cooked meal in the entirely equipped kitchen before heading out to discover...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
THE DELPHINE Luxury Downtown Charleston ...

Welcome to your beautiful getaway in the heart of Downtown Charleston! Located in the striking Cannonborough/Elliotborough District, this handsome home constructed in 2022 is just steps from King Street’s top eateries, stores, and nightlife. Savor...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
Pool! | 2 Blocks to King St | Parthenon ...

Permit Number: 05086The Space: Two homes. Ten bedrooms. Private (heated) pool. Walk to King Street.This broad Charleston getaway is designed for enormous groups who want space to gather without sacrificing privacy. Tucked on a peaceful street just a...

  • Charleston
  • 10 Bedrooms
  • 6 Bathrooms
  • Sleeps 20
The Manor 93A by Guesthouse Charleston

The Manor 93 A is a handsomely designed 1880's Charleston home offering 4 en-suite bedrooms, an open main floor, and a patio ideal for alfresco dining. Only 2.5 blocks to King St, with stores, eateries, and landmarks like the Battery and Market all...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8