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Charleston, SC 4+ Bedroom Vacation Rentals

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363 rentals found
Close 2 DT & Beaches | 4 BR 10 Guests | ...

Summary:Welcome to Coastal Comfort!Unwind in this bright and modern freshly constructed home. It features a cavernous kitchen, four comfortable bedrooms, and a beach-inspired design. Savor complimentary beach gear and make this your ideal home base...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Spacious, Large 4bd w/ Outdoor Dining, n...

Summary:Feel the ideal fusion of history and modern luxury at this exceptional 4-bedroom, 3-bath residence. This charmingly modernized home offers an elevated getaway in the heart of the city. Located just three blocks from vibrant King Street...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 9
The Preserve | Barbados House | 5 BR + 5...

Summary:Welcome to the Barbados House, part of The Preserve, a luxury single-style home located in the heart of downtown Charleston. This alluring 5-bedroom, 5.5-bath residence offers an unparalleled blend of sophisticated appeal and modern comfort...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
BEST Location in Charleston/Downtown /4 ...

Summary:Welcome to your Charleston hideaway, a roomy stand-alone home in the esteemed Cannonborough/Elliotborough district. With a Walk Score of 95, this location puts the city’s best dining, nightlife, and local appeal right at your doorstep, yet...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Beautiful 6BR / 6BA w. Parking, Gym, Wal...

Summary:Welcome to this refined 6-bedroom, 6-bathroom home from The Heirloom collection. Professionally designed and newly remodeled, it offers modren comfort mins. from King Street’s vibrant energy, ideal for enormous groups seeking luxury and...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Historic Charm | The Bee & Blossom

Permit Number: 07286The Space: Welcome to The Bee and Blossom, a delightfully reimagined historic 6-bedroom, 6.5-bath home in the laid-back Radcliffborough neighborhood, thoughtfully designed for groups of up to twelve guests!Spanning three roomy...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Downtown home 5BR & 7 Beds w/ Free Priva...

The Space:- 5 roomy bedrooms, 4 full baths, 2 half baths- Sleeps up to 14 guests—ideal for families, bachelorettes, and groups- Formal dining room with seating for 10- Totally outfitted kitchen with modern appliances- Cozy breakfast nook for...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Downtown 9BR Mansion with Gym Access + P...

Summary:Recently remodeled with two full kitchens and fresh decor, this home comfortably accommodates your entire event. Located in the heart of the city, the Heirloom on Spring opulent getaway blends historic character with modern comfort, offering...

  • Charleston
  • 9 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Where Tranquility Blooms | Blossoms on C...

Permit Number: 07328The Space: Welcome to Blossoms on Cannon, a handsomely restored two story Charleston home designed for comfort, connection, and memorable group stays in the heart of downtown! There will be work taking place at the back of the...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 11
Classic Charleston Home, Steps to King, ...

Summary:Feel Charleston in this beautiful two story, 5 Bedroom + 6 Full Bathroom Home! A classic Charleston Single on Coming Street, steps from famed King Street. Appreciate simple access to local bakeries, coffee stores, top-notch eateries and...

  • Charleston
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Boho Rosa | Famous Pink House with Pool ...

Summary:Welcome to Boho Rosa, a vibrant getaway named one of Condé Nast Traveler’s Top 10 Airbnbs in Charleston three years in a row. Behind its iconic pink exterior, professionally designed boho-chic interiors blend with classic Southern appeal...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Downtown Duplex - Coming St - Sleeps 20

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
 SOUTHERN CHARM! DOWNTOWN CHARLESTON -  ...

Our property is a legally allowed vacation rental as required by Charleston City ordinance. Our certificate of operational number is OP2025-06802One block from the heart of the entertainment district of Upper King Street. You will know you are in...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Cozy Two-Story Home with Outdoor Fun

This cavernous two-story home is designed with families and groups in mind, offering plenty of room to relax, gather, and savor your stay. The home serves as a four-bedroom property with flexible sleeping arrangements, including a king bed in the...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
The Saint | Newly Built Charleston Home ...

Summary:Welcome to The Saint, a freshly constructed Charleston home that showcases striking architectural design and modern comfort in a walkable urban setting. Ideal for families, friends, or style-conscious travelers who savor light-filled spaces...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
Charming 4-bedroom home, 10 Minutes to D...

Totally refreshed in 2025 -- Stay comfortably in Charleston at this 4-bedroom home. Each bedroom features a king bed, ensuring a pleasant nighttime's sleep for all guests. With amenities like a washing machine, WiFi, and AC, your stay will be both...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
East 42 A & B - Entire Ground Floor, 2 U...

East 42 A & B is the combined listing for the two homes below. These two pretty homes can be connected via the fire door in the hallway creating a handsome five bedroom, five bathroom, with a queen murphy bed for flex linens, and two private parking...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Guesthouse Charleston: SOUTH (82 A & B)

82 A & B is a cavernous two-story home, charmingly located within walking distance of Charleston's best eateries, bars, and attractions. Ideal for huge groups, the home features two entirely equipped kitchens, two living areas, and multiple outdoor...

  • Charleston
  • 8 Bedrooms
  • 9 Bathrooms
  • Sleeps 18