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Charleston, SC 4+ Bedroom Vacation Rentals

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356 rentals found
8 Bedroom - Close to King Street - with ...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 8 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
Beautiful King Street 4 Bedroom! 30 Day ...

Summary:Welcome to this freshly remodeled 4-bedroom rental in the heart of downtown Charleston, designed for both relaxation and productivity. Each bedroom features a king-size bed and intelligent TV. For those blending travel with work, two...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Great for Groups | Private Patio | The Z...

Permit Number: 07349The Space: Welcome to Zeus — a freshly redesigned second-floor getaway constructed for comfortable group stays. With 5 bedrooms and 4.5 bathrooms across two upper levels, this cavernous home gives families and bigger groups...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
6C at Saint Philip Square, One Block to ...

Come experience a luxury stay in the heart of Charleston at Saint Philip Square. Our award-winning collection of historic homes spans nearly one city block, The Aiken House, a 4-bed 4-bath second floor gem that blends modern comfort with...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Professionally Designed 5bd Retreat, Ste...

Summary:Welcome to Emerson Square, a enormous professionally designed getaway of a handsomely restored historic building, this broad five-bedroom residence is ideal for families and sizable groups. Savor a chef’s kitchen, SMART TVs throughout...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 15
Downtown Historic Home Close to Neighbor...

Summary:Welcome to this vibrant downtown getaway! Originally constructed in 1905 and newly modernized, this colorful home blends historic appeal with modern comfort. With eight uniquely styled bedrooms and eight gorgeously refreshed bathrooms...

  • Charleston
  • 8 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
Downtown Charleston Home - 1 Block to Ki...

Summary:Welcome to your Charleston hideaway, a designer-refurnished home just one block from King Street that blends style, comfort, and an indoor-outdoor vibe. Ideal for friends or couples who want walkability, thoughtful design, and a backyard...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 12
Quality Design - Downtown - Steps to Kin...

Summary:Welcome to your Charleston stay in Quality Design, a refined home where artistic touches, thoughtful materials, and walkability combine for a stay that feels both opulent and local. Ideal for design lovers, couples or group travelers who...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Luxury, High-End w. Elevator, Parking + ...

Summary:Savor sleek living in this modern 4-bedroom unit at The Charlee. With elevator access, your own EV charger, and a BBQ grille for alfresco evenings, what more could you need. The clean lines and modern decor set the ideal backdrop for...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Charleston Charm: Renovated 4BR House wi...

Summary:Attractively modernized downtown Charleston home available as a 30+ day furnished executive rental. Located just mins. from King Street dining/shopping and an painless walk to Colonial Lake, this bright two-story residence blends classic...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Only 1 Block to King! | The Sweetgrass

Permit Number: 06474The Space: Welcome to The Sweetgrass House, a cavernous two level getaway designed for groups of 8–10 guests looking for comfort, privacy, and an painless downtown Charleston stay. With four bedrooms and four full bathrooms...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Marsh-View Retreat w/Hot Tub I Golf Cart...

Welcome to your peaceful Charleston escape-a roomy, calming home tucked along the marshes of the Ashley River, offering elegant vistas, fresh coastal air, and simple access to everything Charleston is known for.This 4-bedroom, 3.5 bath home is ideal...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Grand 18bd House w Luxury Finishes + Gym...

Summary:As part of the esteemed collection, The Heirloom, this striking 18-bedroom compound is located on Spring Street in the heart of Charleston. Ideal for huge groups, this entirely refreshed property combines two chic Victorian homes with modern...

  • Charleston
  • 18 Bedrooms
  • 14 Bathrooms
  • Sleeps 30
Charming Renovated Retreat for Work + Pl...

Welcome to your newly refreshed (Spring 2026) getaway in the West Ashley neighborhood of Charleston, ideally located down the road from a boat launch, just 15 mins. from the airport, 20 mins. to historic downtown Charleston, and 40 mins. to top...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Guesthouse Charleston: SOUTH (105 ALL)

This combined listing for South 105 A, B, & 105.5 is a great space for enormous groups. Each unit has 4 bedrooms, and 4.5 bathrooms totalling 12 bedrooms, 12 full bathrooms, 3 half bathrooms, 3 full kitchen/living areas. Located on the desired...

  • Charleston
  • 12 Bedrooms
  • 13 Bathrooms
  • Sleeps 28
Bee & Blossom | Large Bed & Breakfast Bu...

Summary:Welcome to Bee & Blossom, a delightfully restored home in Charleston’s historic Radcliffeborough neighborhood. The home blends classic Charleston character with modern comfort. Gather in the inviting living room, prepare meals in the...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Vacation Villa (ADA) 'The Mediterranean ...

Summary:Vacation Villa 5 min. walk to King St, in the heart of downtown Charleston. This tropical getaway offers sleek design, open first floor kitchen & living room, & cavernous bedrooms with en-suite spa bathrooms. Unwind in luxury at...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Beautiful 10bd/10ba Home w. Pool + Parki...

Summary:Discover this massive 10-bedroom, 10-bathroom getaway in downtown Charleston, accommodating up to 22 guests. Luxuriate in open living spaces, a entirely equipped kitchen, and king-size beds throughout. With off-street parking, modern...

  • Charleston
  • 10 Bedrooms
  • 10 Bathrooms
  • Sleeps 24