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Charleston, SC 4+ Bedroom Vacation Rentals

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347 rentals found
Sandy Oaks: The Best of Both Worlds!

Beach? Downtown? Lowcountry experience? You don't have to compromise at Sandy Oaks! Bring your furry friend to savor the cavernous, completely fenced-in backyard, sip wine on the deck, and play foosball in the game room. Located 5 miles to Folly...

  • Charleston
  • 4 Bedrooms
  • 1 Bathrooms
  • Sleeps 8
The Inns | Bright & Breezy Large Luxury ...
4.9
(15)

Summary:Welcome to The Inns! - 5 Bedrooms/3 Bathrooms- Entire 2nd & 3rd Floors of Charleston Victorian Home - Heart of Downtown! Walk to King Street (Walk Score of 95!)- Professionally Designed with Guest Feel in Mind- High-Speed Wifi Throughout and...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 13
The Tropic - Large Jungly Oasis, Great f...

Welcome to the Tropic! Private single-family home with sizable screened-in porch and jungly backyard less than 10 mins. to downtown and 15 to beach. Walkable to coffee stores, bars and dining. Outdoor dining, grille and deck, tropical plants, a work...

  • Charleston
  • 5 Bedrooms
  • 2 Bathrooms
  • Sleeps 12
Charming Avondale Home ~ 5 min from Down...

Welcome to this 3br/2ba home in the highly charming Avondale neighborhood West of the Ashley. In a ideal location only 5 mins. walk to the eateries/bars of Avondale and the West Ashley Greenway and less than a 10 min. drive to Downtown Charleston...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 7
The Rosemary House | Sleeps 16 | Multi-U...

Summary:Welcome to the Rosemary House at The Preserve, a cavernous and elegantly appointed residence occupying the top floors of a handsomely preserved historic home. With 8 bedrooms and 8 bathrooms, this broad property offers ample privacy and...

  • Charleston
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 16
The Chapel | 4BR DT Charleston - Walk Ev...

Summary:NEWLY DESIGNED in March 2024! Welcome to your striking Charleston rental! Set back from the street away from noise but close to all the action, this private second floor unit has 4 bedrooms and 4 private en-suite bathrooms. Wood floors...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Downtown Charleston 8 Bedroom
4.7
(31)

Recently constructed, three-home complex, centrally located in Downtown Charleston! ✦Over 5,000 SQ FT!! ✦ Great for enormous groups - spend time together, but everybody can have their space!✦Open-air porches, welcoming living areas & roomy...

  • Charleston
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 20
Vacation Villa 5 mins to King St- ‘The...
5.0
(1)

Summary:Vacation Villa 5 min. walk to King St, in the heart of downtown Charleston. This tropical getaway offers sleek design, soaring 25’ ceilings, open first floor kitchen & living room, and cavernous bedrooms with en-suite spa bathrooms. The...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
THE INNS Charming 5BR/3BA Heart of Downt...
4.8
(11)

Summary:Welcome to The Inns! We are a brand of luxury vacation homes here in Downtown Charleston. All of The Inns are fresh, freshly modernized, and professionally decorated.- Two Separate Units Make Up 5 Bedrooms, 3 Bathrooms, and 2 Living Rooms ...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 14
Cozy low country get away with water vie...

Roomy home with sizable front and back yard surrounded by naturalistic beauty of low country scenery. Appreciate water view from front deck or sunsets and wild roaming turkeys and deer on covered back deck. Sensational star gazing at nighttime...

  • Charleston
  • 5 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
The Manor 91.5 by Guesthouse Charleston ...
5.0
(1)

Close to the sea, this smoke-complimentary vacation home brings it all within reach. Upper King Design District is an painless 12-min. walk away, so you can leave your car at the property, which offers onsite parking, or jump in your car to make...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Cannon Collective | 5BR Historic Home Do...

Summary:This home offers the ideal mix of appeal and convenience in the heart of the sought-after Cannonborough neighborhood. This cavernous single-family home is ideal for families or groups, placing you steps from Charleston’s best dining...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 15
Beautiful Historic Charleston Home

Welcome to the Holy City, and the historic southern appeal of the Charleston peninsula. Our Vacation Rental By Owner is located in gorgeous downtown Charleston and just mins. away from MUSC, the College of Charleston, and King Street’s shopping...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
EAST 46 G & H - 2 Units, Connected Inter...
5.0
(2)

Two handsome adjoining apartments offering a total of 5 bedrooms, 5 bathrooms, 2 full kitchens, and 2 cavernous living rooms, making them ideal for bigger groups or families seeking both space and comfort. Located just one block from King Street in...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Private Pool Oasis 4 Bedroom Suite

Escape to this impressive 4-bedroom, 2-bathroom vacation rental located in the heart of downtown Charleston, located in the city’s most coveted neighborhood. Ideal for families, friends, or any group seeking an memorable hideaway, this home...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Long Term stay in 4-bedroom house in cha...

House available to rent for 3 month interval min. in 2026 beginning January 15, 2026. Located in Charleston, SC, appreciate all that this 4-bedroom designer home has to offer. With 4 bedrooms and 3.5 baths, guests will have plenty of space to...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 7
Waterfront Escape - Private Pool, Dock, ...
5.0
(1)

Welcome to your ultimate waterfront escape just mins. from Folly Beach and the appeal of downtown Charleston. This cavernous home offers an memorable setting for family vacations, group getaways, or special events. Savor striking water vistas, a...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Luxurious 4BR Downtown Home - Walkable!

Summary:Welcome to "Luxurious 4BR Downtown Home - Walkable!", your ideal Charleston getaway! Located just off King Street in the Crosstown neighborhood, this impressive home offers 4 elegantly appointed bedrooms, each with a private en suite bath...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 9