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Charleston, SC 4+ Bedroom Vacation Rentals

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365 rentals found
BEST Location in Charleston/Downtown /4 ...

Summary:Welcome to your Charleston hideaway, a cavernous stand-alone home in the esteemed Cannonborough/Elliotborough district. With a Walk Score of 95, this location puts the city’s best dining, nightlife, and local appeal right at your doorstep...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Modernized 5BR Family Home?Tranquil Pati...

This handsome 5-bedroom, 2.5-bathroom home is a true gem, located on one of the quietest streets in Charleston. With newly modernized bathrooms, resurfaced floors, and a cavernous, open floor plan, this home is ideal for families or professionals...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Cozy low country get away with water vie...

Cavernous home with enormous front and back yard surrounded by naturalistic beauty of low country scenery. Appreciate water view from front deck or sunsets and wild roaming turkeys and deer on covered back deck. Stunning star gazing at nighttime...

  • Charleston
  • 5 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
The Historic St. Philip House - One Bloc...

Construction Notice (Updated 6/3/26)Daniel and I would like to inform you of a construction project taking place close to this home.UPDATE:- The townhomes next to us will be finished by the end of June, 2026.- The building behind us is supposed to...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
 SOUTHERN CHARM! DOWNTOWN CHARLESTON -  ...

Our property is a legally allowed vacation rental as required by Charleston City ordinance. Our certificate of operational number is OP2025-06802One block from the heart of the entertainment district of Upper King Street. You will know you are in...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Great for Groups | Private Patio | The Z...

Permit Number: 07349The Space: Welcome to Zeus — a newly redesigned second-floor getaway constructed for comfortable group stays. With 5 bedrooms and 4.5 bathrooms across two upper levels, this roomy home gives families and bigger groups room to...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Oak Loft Downtown, Steps to King St Bars...

Summary:Welcome to The Oak Loft, an exceptional 4-bedroom, 3-bathroom top floor unit in the heart of Downtown Charleston. With its distinctive design and creative flair, this one-of-a-kind space offers an inspiring getaway! Located just steps from...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Lowcountry Charm | 4BR Spring St. Home w...

Welcome to the Holy City, and the historic southern appeal of the Charleston peninsula. Our Vacation Rental By Owner is located in charming downtown Charleston and just mins. away from MUSC, the College of Charleston, and King Street’s shopping...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 11
8 Bedroom - Newly Renovated - Parking & ...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
The Manor 93 A&B - 2 Newly Renovated Uni...

Welcome to 93 Spring Street, a gorgeously restored 1880's Charleston home that combines historic appeal with modern amenities. Located just two and a half blocks from King Street, this cavernous home has been thoughtfully divided into two separate...

  • Charleston
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 14
Large 4bd Artists Home, Walk to King

Summary:Some homes make your trip memorable. The Big Palmetto is one of them. This cavernous four-bedroom getaway invites you to slow down, gather with the people you adore, and experience Charleston from one of its most handsome historic...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
New Build | <10 Mins to Folly & <15 to D...

Summary:Welcome to Salt Air Stay!Unwind in this bright & modern NEW CONSTRUCTION home on James Island that sleeps 10 guests with an open layout, and 4 bedrooms and 5 beds. Appreciate the enormous backyard and screened in porch and make this your...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Guesthouse Charleston: WEST (242 B & C)

West 242 B and 242 C are two striking standalone homes located in the heart of Charleston's vibrant Cannonborough/Elliotborough neighborhood, just two blocks from historic King Street. This prime location offers simple access to Charleston's best...

  • Charleston
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
The Preserve | Rosemary House | Rutledge...

Summary:Welcome to the Rosemary House at The Preserve, a cavernous and elegantly appointed residence occupying the top floors of a charmingly preserved historic home. With 8 bedrooms and 8 bathrooms, this broad property offers ample privacy and...

  • Charleston
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 16
The Gardenia House | Unit B | Sleeps 13

Summary:Welcome to the Gardenia House in the Preserve, a refined luxury suite in downtown Charleston featuring 4 roomy bedrooms and 4 full baths. Designed for flexibility and comfort, this pretty suite can be rented separately or combined with the...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 13
4BR Group Retreat, Walk to King St

Summary:Welcome to Blue Magnolia, a roomy and attractively designed Charleston getaway ideally suited for family vacations, group getaways, wedding weekends, and special celebrations. Located in the heart of downtown Charleston, this inviting home...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Sleeps 10-12- Downtown Charleston- AUG &...

We are located on the second floor of a stately antebellum building in the heart of historic downtown Charleston, SC. We offer a private entrance, and five cavernous bedrooms with high ceilings and 19th century heart pine floors, accented with...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 12
True Southern Historic Charm by the Batt...

Step into Charleston’s history with this striking 4-bedroom, 4-bathroom circa-1830 home, just steps from Rainbow Row and The Battery. This extravagant getaway offers period antiques, crystal chandeliers, and grandiose piazzas, blending historic...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 9