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Charleston, SC 4+ Bedroom Vacation Rentals

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359 rentals found
Charming 4-bedroom home, 10 Minutes to D...

Totally refreshed in 2025 -- Stay comfortably in Charleston at this 4-bedroom home. Each bedroom features a king bed, ensuring a pleasant nighttime's sleep for all guests. With amenities like a washing machine, WiFi, and AC, your stay will be both...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Casa Zoë | Cottage Row – Side-by-Side...

Summary:OP2025-05857OP2025-05858Cottage Row is a rare Charleston find with two completely separate, next-door Casa Zoë cottages that together create the ideal setup for groups who want to be close but still have their own space. Tucked in the...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
The Pineapple Place | EastBay Historic D...

Summary:Welcome to your Charleston sanctuary where historic appeal meets cavernous luxury. This 5-bedroom getaway offers a generous 3,000 square feet of gorgeously appointed space. Ideal for families or groups who want chic design, room to spread...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 16
Stunning 6-Bedroom Home with Pool, 5.5 B...

More photos coming soon!Dive in to this freshly refreshed 6-bedroom, 5.5 bathroom home with a brand new pool, ideal for hosting up to 12 guests. This three-story haven, adorned with wood floor, original fireplaces, and high ceilings with exposed...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Game Room• Fireplace • Backyard Deck...

Welcome to Your Storybook Hideaway * 16 miles to Historic Downtown Charleston* 25 miles to Folly Beach and Isle of Palm* 6.4 miles to Charleston International Airport* Free Wi-Fi and self-check-in* Free parking available* Fireplace* Entirely...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Blue Magnolia | Perfect for Large Groups

Summary:Discover Blue Magnolia, your beautiful and cavernous Charleston getaway. This 7BR/4BA home combines classic Southern appeal with modern comfort, making it ideal for families or groups. Unwind on the inviting front porch, soak in the airy...

  • Charleston
  • 7 Bedrooms
  • 4 Bathrooms
  • Sleeps 17
Great for Groups | Private Patio | The Z...

Permit Number: 06281The Space: Welcome to Zeus — a freshly redesigned second-floor getaway constructed for comfortable group stays. With 5 bedrooms and 4.5 bathrooms across two upper levels, this cavernous home gives families and bigger groups...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
8 Bedroom - Close to King Street - with ...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 8 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
Where Tranquility Blooms | Blossoms on C...

Permit Number: 06351The Space: Welcome to Blossoms on Cannon, a gorgeously restored two story Charleston home designed for comfort, connection, and memorable group stays in the heart of downtown!Bedrooms & Bathrooms• Five bedrooms thoughtfully...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 11
5BR Rooftop Home with Parking Near King ...

Summary:Discover the Palmetto on Spring, a striking 5-bed, 5.5-bath Charleston getaway. This modernized home spans three floors, featuring a detached guesthouse and a private rooftop terrace with city vistas. Ideal for huge groups, it's just a...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
New design & construction, 6 Bed, 6 EnSu...

Welcome to 183 Saint Philip Street, your chic haven in the heart of Charleston! This new construction offers a prime location, placing you steps away from the city's vibrant attractions & best eateries. Each bedroom features 55" Samsung TVs ...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Brand New, Chic 5 Bed Rental with Porch,...

Summary:Feel modern luxury in historic Charleston at The Hawthorne! This brand-new 4-bed, 4-bath home is steps from King Street's vibrant energy. Ideal for groups, it features a full kitchen, private balcony, and enormous comfortable living room for...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Lowcountry Charm | 4BR Spring St. Home w...

Welcome to the Holy City, and the historic southern appeal of the Charleston peninsula. Our Vacation Rental By Owner is located in handsome downtown Charleston and just mins. away from MUSC, the College of Charleston, and King Street’s shopping...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 11
1 Block to King St | Plunge Pool | Sleep...

Summary:Feel luxury at The Pink Palm, a impressive new construction 4-bedroom, 4-bathroom getaway in downtown Charleston finished in APR 2025. Appreciate cavernous living areas, extravagant baths, and a completely equipped kitchen. Unwind in the...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Newly Built, 4bd Luxury Suite steps to K...

Summary:Discover this freshly constructed 4BR/3BA home on Charleston’s downtown peninsula, blending modern design with classic details. Set on the second floor of a refreshed building, it offers a peaceful escape just steps from stores, cafes, and...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 9
Rare 4bd in Historic District, Steps to ...

Summary:Welcome to Pineapple Pad, your extravagant escape located in Charleston’s East Bay Historic District. This modren getaway is constructed for guests who adore refinement, space, and rich Charleston appeal. Ideal for families, friends, or...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 14
Downtown Charleston Home + Private Pool

Summary:Ideal for a sizable family! This listing is for the entire home. The home sleeps 16 guests total. Your stay just got an upgrade. 118B President Street now features a newly finished private plunge pool, sun deck with loungers, and outdoor...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Charleston Duplex Home 5BR - Walk to Kin...

Welcome to the Holy City, and the historic southern appeal of the Charleston peninsula. Our Vacation Rental By Owner is located in gorgeous downtown Charleston and just mins. away from MUSC, the College of Charleston, and King Street’s shopping...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10