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Isle of Palms, SC 6+ Bedroom Vacation Rentals

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63 rentals found
Award-Winning Resort Amenities | Beachwo...

Beachwood East 19 by Wild Dunes7 Bedroom | 7 Bathroom | Sleeps 16 | Oceanfront _____________________________________Welcome to Beachwood East 19, a gorgeous getaway on Isle of Palms’ exclusive Wild Dunes Resort. Feel island living in this...

  • Isle of Palms
  • 7 Bedrooms
  • 9 Bathrooms
  • Sleeps 16
712 Ocean Blvd | New Build + Pool, Game ...

Sun, sand, and wellness collide at Stay Salty—a brand-new, oceanfront getaway on Isle of Palms where modern luxury meets intentional, healthy living. With six bedrooms (including 5 California King beds), six full bathrooms, and a powder room, this...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
BRAND NEW BUILD; Gorgeous home with POOL...

Welcome to your Isle of Palms escape at 3806 Cameron Boulevard—a gorgeous 6-bedroom coastal getaway designed for memorable beach vacations with family and friends.Located on the 3rd row of homes on the island and just steps from the sand, this...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 14
700 Ocean Blvd | 6BR/6.5BA | Oceanfront ...

Oceanfront luxury awaits at 700 Ocean Blvd on Isle of Palms, where a cavernous 6-bedroom, 6.5-bath home offers room for up to 14 guests just steps from the sand. Guests rave about the unbeatable ocean vistas, generous gathering spaces, and fun...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 14
Stunning Brand NEW Build, 6 bd OCEANVIEW...

Welcome to your BRAND NEW Isle of Palms beach getaway, where thoughtful design, elevated amenities, and effortless coastal living come together just steps from the beach. Located on a peaceful street and ideal for sizable groups, this striking new...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 14
Brand New Custom Oceanfront home- Stunni...

Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in handsome, luxury or budget friendly vacation...

  • Isle of Palms
  • 6 Bedrooms
  • 8 Bathrooms
  • Sleeps 12
Private Pool + Beach Access + Resort Ame...

Fishers Alley 5 by Wild Dunes6 Bedrooms | 6 Bathrooms | Sleeps 12 | Reserve________________________________________Welcome to Fishers Alley 5, a gorgeous getaway on Isle of Palms’ exclusive Wild Dunes Resort. Just a block and a half from the...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
'Isle be Back' 5 57th Ave- Great Ocean V...

**Summer bookings are Sat. to Sat. We have a 3 nighttime min in the off-season** Description"Isle be Back" - 5 57th Avenue is one of our newest additions. It is a splendid, six bedroom, five and a half bathroom inverted floor plan home with...

  • Isle of Palms
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 16
Newly Built IOP Home – Pool, Ping Pong...

The Eleanor House – Modern Elegance with Private Pool & Coastal CharmWelcome to The Eleanor House, a impressive new build on Isle of Palms offering the ideal blend of refined coastal design and effortless vacation comfort. Just a 5-min. walk to...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
3 53rd Ave Stunning Ocean Views, Pool, H...

--Description--'Beach Bliss', 3 53rd Ave, is an enchanting and freshly constructed masterpiece. This striking property showcases six roomy bedrooms each adorned with 10-foot ceilings and opulent ensuite bathrooms. Located on a serene street at the...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Discounts! OCEANFRONT STUNNER- Discounte...

**Ask about our current discounts for Spring/Summer 2026!Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We...

  • Isle of Palms
  • 7 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
3100 Palm Boulevard by AvantStay | Beach...

3100 Palm Boulevard, "One Summer Dream"Many great novels of the South focus on the South Carolina Low Country and its phenomenal beaches, spawning dreams of life on its idyllic coast. These images can be your reality when you plan your next...

  • Isle of Palms
  • 7 Bedrooms
  • 8 Bathrooms
  • Sleeps 12
Paradise awaits! 7 Bedroom, Private Neig...

Isle of Palms Getaway – Pool, Beach, Dining & Fun Right Outside Your Door!Everything you need for the ideal beach vacation is right at your fingertips! This handsome Isle of Palms home sleeps up to 14 guests, with 7 roomy bedrooms and 5 full...

  • Isle of Palms
  • 7 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Casa Flamingo Oceanfront Dreamhouse! 8 b...

Welcome to Casa Flamingo! Presented by Exclusive Properties on Isle of Palms. *Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. **Available all year! During the Summer months...

  • Isle of Palms
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 19
Second row back from the beach, cornhole...

One row back from the beach! This ocean view, 9 bedroom 6 and a half bath home is loaded with amenities for your family getaway. Charm and coastal style are found throughout this pretty vacation home which has an in ground pool, enormous yard with...

  • Isle of Palms
  • 9 Bedrooms
  • 6 Bathrooms
  • Sleeps 20
1 Block to Beach, Newly Renovated 6BDR w...

Welcome to Sand Dune. Heaven beckons from this marvelous beach home that's located only 1 block away from the sandy shores of Isle of Palms Beach. Recently refreshed in 2025, Sand Dune now features major upgrades to the kitchen and bathrooms...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
????'Dolphin Manor' ~ OCEAN FRONT, PRIVA...

** During the summer and holidays we book Saturday to Saturday. Off-season we require a 3 nighttime minimum **Description'Dolphin Manor' -512 Ocean Blvd, was entirely refreshed and is the ideal oceanfront home for your hideaway! With light filled...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Discounts! Beautifully decorated 206 Oce...

Ask about our Spring/Summer 2026 discounts! **This home books Friday to Friday in the Summer months**--Description--Part of our luxury collection, 'Villa Las Palmas', 206 Ocean Blvd., is a seven bedroom, seven and a half bathroom oceanfront home...

  • Isle of Palms
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 12