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Isle of Palms, SC 2+ Bedroom Vacation Rentals

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345 rentals found
28 Pelican Bay! Wild Dunes Family Vacati...

Welcome to your ideal coastal getaway at 28 Pelican Bay! This striking and inviting 4-bedroom beach home is located in a calming, oceanside neighborhood, just a leisurely 3–4 min. walk from the pristine shoreline. Ideal for families, this home...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
311 Summerhouse by AvantStay | Beach Vie...

A handsome pearl might surprise you when opening an oyster, but you will always find a handsome vacation when opening the door at 311 Summerhouse. This magnificent oceanfront, three-bedroom and three bath condominium newly experienced an broad...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 7
Screen porch, Golf Cart, Pet friendly, L...

All new reservation (3-21 nights) will receive $250 credit toward beach gear units with VayK Life!Charming Island home with hot tub! Unwind in the living room with flat-screen TV, den, and 2 front verandas, all with ample seating. Entirely supplied...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Oceanfront Condo in Wild Dunes! Communit...

Escape to Isle of Palms in this adorable 2-bedroom, 2-bathroom condo with sweeping vistas of the majestic Atlantic Ocean. Besides having fantastic ocean vistas and a great location, you'll also be in the Wild Dunes Resort, where you can reserve a...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
521 Carolina Blvd ~ new construction com...

521 Carolina Blvd - Lil’ Pink HouseIsle of Palms, SCOverview: Welcome to “Lil’ Pink House,” a brand-new 6-bedroom, 6.5-bathroom bespoke home finished in March 2024. This striking property offers an unparalleled blend of sophistication and...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Steps to the Beach! Pool, Game Room, Mov...

Discover the ultimate beach vacation at 3301 Palm! Featuring six bedrooms and sleeping 14 guests, this cavernous getaway is the ideal choice on the Island for your next group hideaway. This 3-story home features a private pool, movie theater...

  • Isle of Palms
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Oceanfront Shipwatch Wild Dunes - END UN...

Welcome to your dream vacation rental on Isle of Palms! This newly refreshed, beachfront villa in the Shipwatch community of Wild Dunes is an end-unit boasting gorgeous ocean vistas and the ideal hideaway for families or groups of up to 8...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Stunning IOP Home:  Hot Tub, Private Poo...

Looking for the ideal home for your next Charleston beach vacation? You found it! Welcome to Heads Carolina at 3101 Waterway, one of our most fashionable listings!Some of our favorite features:Waterway, Golf and Sunset VistasPrivate Pool with Hot...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
CLASSIC and Cozy IOP Beach Home, Family-...

Great Family Friendly 5 bedroom home located on a corner lot. Only two blocks from the IOP marina and close to the beach. This home is boat friendly with simple access to the IOP Boat Ramp. You will adore how this home can accommodate a very huge...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
Ocean View Home in Gated Wild Dunes on G...

Escape to a dreamy Isle of Palms beach vacation at this striking oceanfront four-bedroom vacation rental home located in the highly sought-after and private neighborhood of Ocean Point, located on the northern tip of the Wild Dunes Resort. This...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Stunning completely remodeled 3 bedroom ...

Wild Dunes Ocean Club VillaLocation: Isle of Palms, SCOverview:Welcome to Ocean Club Villas 4302, a charmingly refreshed 3-bedroom, 3-bath villa located on the 3rd floor in the acclaimed Wild Dunes Resort on the Isle of Palms. This impressive...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Charming Beach Cottage with Lagoon views...

Charming Beach Cottage. Designer Furnished with rich hard wood floors. Grand Kitchen with Screened Porch overlooking the Pelican Bay Lagoon. Soaring Vaulted Ceilings in Living Room. Ample parking for 4 cars. Substantial LCD TVs in Living Room and...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
3 Twin Oaks Lane by AvantStay | Beach Ac...

It is said that "family holidays are valued by kids, both in the moment and for long afterward in their memory". 3 Twin Oaks Lane is ready to welcome your family to their next fabulous memory while spending a holiday at the beach!3 Twin Oaks Lane...

  • Isle of Palms
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Oceanfront Villa in Wild Dunes Hot Tub &...

Construction Notice: This property will be undergoing major renovations during 2025. We are excited to see all of the marvelous exterior updates that will be made.​​​​​​​Plan the ultimate escape at this striking and very roomy Ocean...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Top floor 3-Bedroom Villa with Ocean Vie...

Shipwatch C421Isle of Palms, South CarolinaOverview:Welcome to Shipwatch C421, a three bedroom and three bath condo located in the Wild Dunes Resort on the Isle of Palms. This vacation home was refreshed in spring 2025 with new living room...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 6
Ocean Club 4209 by Wild Dunes, Oceanfron...

Ocean Club 4209 by Wild Dunes3 Bedrooms | 3.5 Bathrooms | Sleeps 8 | Oceanfront________________________________________With a complex pool and unparalleled oceanfront vistas, this 2257 Sq. Ft. Ocean Club condo provides a relaxing and sophisticated...

  • Isle of Palms
  • 3 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
11E Mariners Walk by AvantStay | Ocean V...

Look no further at 11 E Mariners Walk to find your dream vacation destination! This well-appointed condominium is uniquely designed with three levels, offering oceanfront vistas from not only the living area but also two bedrooms! Featuring...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Golf Views, Private Pool, Screen Porch, ...

5 Bedroom, Private Pool, 12th Green on Harbor Course, Close to Isle of Palms Marina. $250 credit toward beach gear units with VayK Life (3-21 nights only). Ideal Family Getaway! Off season discounts and long-term units available until March 2025...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10