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Isle of Palms, SC 2+ Bedroom Vacation Rentals

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339 rentals found
PRIME Resort Location! Beachside, Ocean ...

Everything you are looking for in a beach vacation on the SC coast can be found at this striking two-bedroom villa located in Wild Dunes Resort. The Seagrove Villas is a fabulous community of well-maintained condos surrounded by lush greenery...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Modern Beach Home w/Private Pool, 3 Mast...

802 Palm BlvdIf you're ready to take a deep dive into the luxury lifestyle on Isle of Palms, SC, then this is the property for you! This exceptional 4-bedroom home has 4 bathrooms and 2 half bathrooms, and ideally sets you up to experience all the...

  • Isle of Palms
  • 4 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
322 D Shipwatch by AvantStay | Community...

_Note: The Shipwatch complex will be undergoing renovations from November 12, 2026 through February 2027. Each building is expected to be impacted for roughly 6–8 weeks during the project. While the condos will remain accessible, the work is...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Abalone Alley 04 - Easy Breezy  - Privat...

4 Abalone Alley | Painless BreezyIsle of PalmsOverview:Welcome to Simple Breezy! The name says it all! This delightfully refreshed 5 bedroom-4 bath home has top notch finishes in the brand new kitchen and baths. Throughout the bright and open floor...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Stay @ Path to Paradise on Isle of Palms

Path to HeavenLocation: Wild Dunes, Isle of Palms, South CarolinaOverview:Welcome to 20 Beachwood West, a striking 4-bedroom, 3.5-bathroom vacation home located in the heart of the beautiful Wild Dunes community. This brand-new construction combines...

  • Isle of Palms
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Stay @ Will-o-Layne on Isle of Palms

2401 Palm | Will-o-LayneLocation: Isle of Palms, South Carolina Overview:Welcome to Will-o-Layne, a gorgeous and roomy 5-bedroom, 3-bathroom family beach bungalow located directly across from the ocean on the Isle of Palms. This beautiful home...

  • Isle of Palms
  • 5 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Award-Winning Resort Amenities | Lagoon ...

Lagoon Villa 36 by Wild Dunes2 Bedrooms | 2 Bathrooms | Sleeps 8 | Resort View________________________________________Set alongside a relaxing lagoon, this 1241 Sq. Ft. Lagoon Villas home provides a peaceful coastal getaway with access to a complex...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Ocean View + Private Hot Tub + Resort Am...

Conch Court 3 by Wild Dunes4 Bedrooms | 4.5 Bathrooms | Sleeps 8 | Ocean View________________________________________Welcome to Conch Court 3, a striking getaway on Isle of Palms’ exclusive Wild Dunes Resort. Located among majestic oak trees, this...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
412 Seascape by AvantStay | Oceanfront +...

Elevate your coastal living experience in this elegant two-bedroom oceanfront condo located within the heart of Wild Dunes. This exceptional residence, distinguished by its dual master bedrooms, offers a unique blend of sophistication and comfort...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Paradise awaits! 7 Bedroom, Private Neig...

Isle of Palms Getaway – Pool, Beach, Dining & Fun Right Outside Your Door! Everything you need for the ideal beach vacation is right at your fingertips! This charming Isle of Palms home sleeps up to 14 guests, with 7 cavernous bedrooms and 5 full...

  • Isle of Palms
  • 7 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Saltwater Sanctuary | Ocean Views + Priv...

The Delaney House – Relaxed Coastal Luxury on Isle of PalmsWelcome to The Delaney House, a elegantly refreshed Isle of Palms getaway where ocean vistas, casual coastal interiors, and a private saltwater pool create the ideal backdrop for an...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Oceanfront w/ Pool + Beach Access & Balc...

_Note: The Shipwatch complex will be undergoing renovations from November 12, 2026 through February 2027. Each building is expected to be impacted for roughly 6–8 weeks during the project. While the condos will remain accessible, the work is...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 6
Lagoon View, Walk to Beach: 5-7 min, Res...

Remodeled in 2024 with all rooms newly painted, refinished wood floors throughout, and a new kitchen. Incredible 5 Bedroom vacation home in the exclusive gated Ocean Point Community of Wild Dunes Resort. Access to the Ocean Point community pool...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Gorgeous Beach Home, Ocean Views, w/Priv...

Welcome to 811 Ocean Boulevard on Isle of Palms! – An Enchanting Coastal RetreatStep into a realm of comfort and appeal as you discover this charming five-bedroom, five-bathroom home located in the heart of Isle of Palms, a heaven for both...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Pool, Spa, Ocean Views, One Block to Bea...

The Josephine House – Coastal Elegance Meets Laid-Back LuxuryWelcome to The Josephine House, a refined 4-bedroom, 4.5-bath sanctuary located along a calming street on Isle of Palms, just steps from the beach and close to the Isle of Palms Marina...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Award-Winning Resort Amenities | Twin Oa...

Twin Oaks 24 by Wild Dunes3 Bedrooms | 2 Bathrooms | Sleeps 6 | Golf View________________________________________Twin Oaks enjoys a prime setting just moments from appealing stores, gourmet eateries, and the energetic center of the resort. Designed...

  • Isle of Palms
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Spacious, Family Beach Home! Ping Pong, ...

Welcome to #32 - 41st Ave! This cavernous, remodeled five-bedroom beach home has a modern look, comfortable feel, and is ideal for your family to appreciate a beach vacation! Property Highlights- 3 Living Areas - All with Intelligent TVs- Free High...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Award-Winning Resort Amenities | Mariner...

Mariners Walk 12C by Wild Dunes2 Bedrooms | 2 Bathrooms | Sleeps 4 | Oceanfront________________________________________Located only mins. from the beach, this 1104 Sq. Ft. Mariners Walk unit features a complex pool and warm, family-friendly...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 4