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Isle of Palms, SC 2+ Bedroom Vacation Rentals

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342 rentals found
Oceanfront Views, Community Pool, Great ...

Located in the charming Seagrove Villas in Wild Dunes Resort, this top floor, oceanfront, two-bedroom condo is the ideal spot! Take in the ocean breeze and the handsome Atlantic Ocean from your balcony, which is only 25 yards from the beach. The...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 4
Oceanfront, Renovated w/ screened porch ...

This oceanfront townhome has been freshly refreshed and professionally decorated throughout. Appreciate plenty of space for up to 8 guests in this 3 bedroom, 3 bath Villa. Located in the prime location of Wild Dunes and located with direct beach...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
3 Twin Oaks Lane by AvantStay | Beach Ac...

It is said that "family holidays are valued by kids, both in the moment and for long afterward in their memory". 3 Twin Oaks Lane is ready to welcome your family to their next excellent memory while spending a holiday at the beach!3 Twin Oaks Lane...

  • Isle of Palms
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
88 Grand Pavilion | AvantStay | Near Bea...

Savor a break from your hectic pace at 88 Grandiose Pavilion. Located on a cozy tree-lined street, this 5 bedroom, 4.5 bath home is a modern beach bungalow that is located in the heart of Wild Dunes. Finest yet, it is only a three-min. walk to the...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Discounts! Sea Spray- 400 Ocean Blvd. Oc...

Ask about our discounts for Spring/Summer 2026!Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 15
Wonderful New Construction Home w/ Priva...

Check your cares at the door and settle into vacation mode at this impressive Isle of Palms hideaway! Located just two blocks from the beach and only steps from the eateries and amenities of Wild Dunes Resort, this home really offers the best of...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Premier, Modern Home with Pool! Great IO...

Welcome to Three Oaks!This Isle of Palms beach home is one of our most opulent rental properties and is the ideal spot for your next vacation! Located less than 5 mins. walking to the beach via access paths at either 23rd or 25th Avenue, it...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Walk Off OCEANFRONT Balcony to Beach! Co...

Location Location Location! This true beachfront 3 bedroom villa offers one of the best vistas in Wild Dunes. 101 Summerhouse is only steps to and from the beach and pool, making it ideal for your next vacation. With the exception of one bedroom...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 6
Luxurious 5BR Oceanview Home with Pool â...

6 54th Ave | Blue HavenIsle of Palms, SCOverview:Welcome to "Blue Haven," a spectacular 5 bedroom and 5 ½ bath home with a pool and ocean vistas. This enormous home has 2 broad living rooms and each have access to a cavernous veranda with...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Modern Grand Pavillon Home: Steps to Bea...

Welcome to 72 Grandiose Pavilion! This idyllic island home is located in the trendy Grand Pavilion neighborhood in the heart of the gated community of Wild Dunes Resort. With access to the boardwalk & oceanfront pools and just steps from the...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Shipwatch C317: Oceanfront Escape in Wil...

Perched above the palm trees and looking out on the water of the Atlantic, this three bedroom, three bath Shipwatch villa offers a comfortable getaway for your Isle of Palms vacation. Savor gorgeous interiors, expansive vistas of the ocean and lush...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 7
OCEANFRONT Views, Modern and Updated, Co...

Having newly undergone an broad remodel, this oceanfront villa is now back on the rental market. Located in simply one of the best areas in Wild Dunes Resort, it's the ideal vacation spot and just steps from the beach and community pool.This roomy 3...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 7
Private Pool, Game Room with Ping Pong T...

Snowbirds Welcome!!Winter Escape to IOP.....Property Description Discover the pinnacle of luxury beach living at this exquisitely designed beach home, located in the heart of Isle of Palms, South Carolina. This impeccable getaway blends coastal...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Steps to Isle of Palms Beach w/ Porch Di...

Welcome to Sea Haven by AvantStay!Just steps from the shimmering shores of Isle of Palms, Sea Haven is a bright, coastal escape designed for effortless beachside living. Located among swaying palms and serene island streets, this home offers the...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Ocean View Home in Gated Wild Dunes on G...

Escape to a dreamy Isle of Palms beach vacation at this impressive oceanfront four-bedroom vacation rental home located in the highly sought-after and private neighborhood of Ocean Point, located on the northern tip of the Wild Dunes Resort. This...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
123D Shipwatch by AvantStay | Beach Acce...

Welcome to 123D Shipwatch! Located in a gated community, this handsome 3 bedroom condo on the first floor features direct beach access and simple access to the pool, making it the ultimate Isle of Palms getaway. Step inside to discover a bright...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Spacious, Family Beach Home! Ping Pong, ...

Welcome to #32 - 41st Ave! This cavernous, refreshed five-bedroom beach home has a modern look, comfortable feel, and is ideal for your family to savor a beach vacation! Property Highlights- 3 Living Areas - All with Intelligent TVs- Free High Speed...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
35 Beach Club Villa by AvantStay | Ocean...

The Beach Boys once said, "On the beach, you can live in bliss." You and your family will find ideal happiness during your next vacation "Beachfront Bliss " at 35 Beach Club Villa. 35 Beach Club Villa features three bedrooms with three full baths...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 7