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Isle of Palms, SC 5+ Bedroom Vacation Rentals

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130 rentals found
Near Beach 5BR/5.5BA Isle of Palms w/ Pr...

Bright and cavernous near the beach on Isle of Palms, this welcoming 5-bedroom, 5.5-bath home is designed for painless coastal living and memorable group getaways. With room for up to 12 guests, it blends comfort, convenience, and a casual vacation...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Award-Winning Resort Amenities | Beachwo...

Beachwood East 19 by Wild Dunes7 Bedroom | 7 Bathroom | Sleeps 16 | Oceanfront _____________________________________Welcome to Beachwood East 19, a striking getaway on Isle of Palms’ exclusive Wild Dunes Resort. Feel island living in this gorgeous...

  • Isle of Palms
  • 7 Bedrooms
  • 9 Bathrooms
  • Sleeps 16
Seascapes 714 Ocean Blvd. Charming, Ocea...

**We are Saturday to Saturday in the Summer, but we have a 3 nighttime min in the off-season**--Description--'Seascapes' 714 Ocean Blvd, is a classic oceanfront home located in the esteemed Ocean Blvd. side of the island which places the beach just...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
NEW CUSTOM HOME 620 Ocean Blvd. Now book...

Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in elegant, luxury or budget friendly vacation...

  • Isle of Palms
  • 7 Bedrooms
  • 9 Bathrooms
  • Sleeps 12
Stunning Brand NEW Build, 6 bd OCEANVIEW...

Welcome to your BRAND NEW Isle of Palms beach getaway, where thoughtful design, elevated amenities, and effortless coastal living come together just steps from the beach. Located on a peaceful street and ideal for sizable groups, this striking new...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 14
Luxe Isle of Palms Retreat • Pool + Fi...

Sparrow House brings a refined, coastal ease to Isle of Palms — a five-bedroom getaway where soaring ceilings and curated interiors set an unhurried, elevated mood. High-end finishes carry through the whole home, which leans into that simple pull...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Private Pool + Rooftop Ocean Views

All Decked Out – Relaxed Coastal Luxury with Rooftop Ocean VistasWelcome to All Decked Out, a elegantly designed Isle of Palms getaway where laid-back coastal living, broad outdoor spaces, and elevated beach home comfort create the ideal setting...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Private Pool, luxe interiors, 1-block to...

The Grace House – Coastal Elegance with Private Pool & Prime LocationTucked just behind the gates of Wild Dunes Resort, The Grace House is an extravagant, 5-bedroom, 4.5-bathroom getaway designed for fresh coastal living. With chic interiors...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Discounts! Sea Spray- 400 Ocean Blvd. Oc...

Ask about our discounts for Spring/Summer 2026!Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 15
1 block to beach! 500 Carolina Blvd. 5 b...

Tired of looking through tons of listings? Do you need a specific type of home or dates? We are a local family owned company, Exclusive Properties, located right here on Isle of Palms. We specialize in handsome, luxury or budget friendly vacation...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Spacious Coastal Home with Private Pool ...

Book June 13-20, 2026 and receive a complimentary golf cart rental for the week! BR 1: King, BR 2: King, BR 3: King BR 4: King, BR 5: King, BR 6: King, BR 7: King, BR 8: 2 Queens, BR 9: 2 Twin, BR 10: 2 Twin; Sleeps 22, Near Beach, Private Pool...

  • Isle of Palms
  • 10 Bedrooms
  • 7 Bathrooms
  • Sleeps 22
Updated Wild Dunes 5BD Steps from Beach-...

Ever wonder what a true resort beach vacation near Charleston would be like? Then it's time to experience "LIVIN' ON A DUNE"!Located in the heart of Wild Dunes Resort on the Isle of Palms and just a block away from the pristine beach, this...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Golf Views, Private Pool, Screen Porch, ...

5 Bedroom, Private Pool, 12th Green on Harbor Course, Close to Isle of Palms Marina. $250 credit toward beach gear units with VayK Life (3-21 nights only). Ideal Family Getaway! Off season discounts and long-term units available until March 2025...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
712 Ocean Blvd | New Build + Pool, Game ...

Sun, sand, and wellness collide at Stay Salty—a brand-new, oceanfront getaway on Isle of Palms where modern luxury meets intentional, healthy living. With six bedrooms (including 5 California King beds), six full bathrooms, and a powder room, this...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
BRAND NEW BUILD; Gorgeous home with POOL...

Welcome to your Isle of Palms escape at 3806 Cameron Boulevard—a impressive 6-bedroom coastal getaway designed for memorable beach vacations with family and friends.Located on the 3rd row of homes on the island and just steps from the sand, this...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 14
Beach Access Directly Across Street! Oce...

Brand New Construction! Ocean Thriller at 903 Ocean Boulevard on the Isle of Palms is a Ocean view, 6 bedroom, 6 ensuite, and 2 half bath, bespoke-constructed home as of 2024. Located in a premier spot with the beach just across the street...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
311 Carolina by AvantStay | Rooftop Ocea...

311 Carolina Boulevard is really a rare find with ocean vistas, private pool, four cavernous decks, and striking amenities to meet your every vacation wish. Step into your vacation dream that features five bedrooms, each with a king bed, four full...

  • Isle of Palms
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Stunning Home! Pool, Theater Room, Steps...

$200 Gift Card Special for WEEK stays!Qualifying weeks are - June 27th - July 11th. Amazing luxury rental located on a peaceful street just a few steps to the beach boardwalk. Loaded with outdoor amenities including an broad backyard complete...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 11