Charleston-SC.com logo

Isle of Palms, SC 2+ Bedroom Vacation Rentals

Filter 2+ Bedroom Isle of Palms Properties by: Company | Oceanfront | Pet-Friendly | or choose different a Area or Bedrooms
No company options available.
Bedrooms:
337 rentals found
Luxurious 3-Bedroom Villa with Ocean Vie...

C118 Shipwatch | The Crow's NestWild Dunes | Isle of PalmsOverview: Welcome to your striking oceanside getaway perched within the exclusive gated community of Wild Dunes. Surrounded by floor-to-ceiling windows, this corner villa is bathed in natural...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 6
Modern Condo, Pool, Close to Beach, Rest...

Desirable first floor condominium located on Ocean Boulevard, this property is just steps from the ocean, park, and access to the only private fishing pier on the island.Very comfortable, smoke-complimentary, family friendly unit located in the 'A...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 5
Oceanfront w/ Gorgeous Views! Classic Be...

Cruise down Palm Blvd to find the most ideal beach vacation home, ideal for a family hideaway to Isle of Palms! This 5-bedroom, 4-bathroom home is the quintessential oceanfront escape, and offers an elegant location close to island eateries and...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Beautifully Remodeled Modern, Yet Charmi...

Your Isle of Palms Heaven Awaits!✨Property Highlights- Private Pool & Putting Green- Ocean Vistas from Second Level- Modern Beachy Decor- Steps to Public Beach Access- $250 Beach Gear Credit with 3-14 nighttime stays!Please note that every...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Beachfront, Pool Access, Balcony w/ Ocea...

_Note: The Shipwatch complex will be undergoing renovations from November 12, 2026 through February 2027. Each building is expected to be impacted for roughly 6–8 weeks during the project. While the condos will remain accessible, the work is...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Outdoor Oasis~Dune Ridge Lane

34 Dune Ridge Lane | Off CourseLocation: Wild Dunes | Isle of Palms, SCOverview:Welcome to “Off Course!" This handsome home is located in Wild Dunes on the 9th hole of the famed Links golf course. Ideal for a beach hideaway, this property offers a...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
IOP Home, Ocean and Intracoastal Views! ...

Welcome to this fun beach hideaway on the southern end of the Isle of Palms, where relaxation meets Lowcountry living. Located just a short 3-min. walk from the ocean near Breach Inlet, this three-level haven with private pool, spectacular indoor ...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Oceanfront Villa in Wild Dunes w/2 Maste...

Construction Notice: Building 1 will be undergoing major renovations during 2025. This condo is located in Building 4 and will be impacted by noise. Please inquire for more details prior to booking. We are excited to see all of the magnificent...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Lagoon view, screen porch w/ swing bed, ...

All 2026 reservation will receive $250 credit toward beach gear units with VayK Life! *3-21 nights only2026 Beach Restoration UpdateThe City of Isle of Palms has approved a beach nourishment project planned for Summer-Fall 2026. Although the final...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Gorgeous Beach Home, Ocean Views, w/Priv...

Welcome to 811 Ocean Boulevard on Isle of Palms! – An Enchanting Coastal RetreatStep into a realm of comfort and appeal as you discover this delightful five-bedroom, five-bathroom home located in the heart of Isle of Palms, a heaven for both...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Fabulous Modern IOP Home! Pool and Hot T...

Escape to this gorgeous 5-bedroom, 4-bath beach vacation rental at 10 Wills Way on the Isle of Palms, just 20 mins. from historic Charleston. This property is new to the rental market and features all-new furnishings, offering modern comfort with a...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Amazing Island Home, Private Pool, Close...

BR 1: King, BR 2: Queen, BR 3: King, BR 4: Queen ; Sleeps 10, Private Pool, Near Beach, HouseAll new reservation (3-21 nights) will receive $250 credit toward beach gear units with VayK Life!This striking bespoke constructed home, located in the...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Family Friendly -New Pool & Spa, 100 Yar...

The Laurel House – Secluded Elegance, Steps from the BeachWelcome to The Laurel House, a 4-bedroom, 4-bath coastal getaway that blends spa-like serenity with classic beachside appeal. Located just 100 yards from the ocean, and surrounded by...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
311 Summerhouse by AvantStay | Beach Vie...

A handsome pearl might surprise you when opening an oyster, but you will always find a elegant vacation when opening the door at 311 Summerhouse. This magnificent oceanfront, three-bedroom and three bath condominium freshly experienced an broad...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 7
Award-Winning Resort Amenities | Twin Oa...

Twin Oaks 24 by Wild Dunes3 Bedrooms | 2 Bathrooms | Sleeps 6 | Golf View________________________________________Twin Oaks enjoys a prime setting just moments from gorgeous stores, gourmet eateries, and the energetic center of the resort. Designed...

  • Isle of Palms
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Private Pool, Elevator, 4-Seater Golf Ca...

Incredible 5 Bedroom, 4.5 bath home with new elevated Salt Water Pool, fresh furnishings and coastal décor. Executive Kitchen with Sub Zero, Wolf and Bosch appliances entirely equipped for the cooks on vacation. The dining Room seats 8 with room...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Cozy, Yet Spacious Family Beach Home w/P...

Get ready for an impressive and fun-filled beach vacation when you select handsome accommodation for your stay. At Carroll Realty, we are excited to tell you about this cavernous vacation home located right by the ocean. Walk a few steps to savor...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 13
Expansive Oceanfront Palm Blvd. 5Bd w/ P...

For those looking to experience a true oceanfront beach vacation on the Isle of Palms, this charming 5 bedroom home located along beautiful Palm Boulevard is the ideal spot for your next beachfront island hideaway! This home offers beautiful ocean...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12