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Charleston, SC 2+ Bedroom Vacation Rentals

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1067 rentals found
Picture Perfect Charleston Living on Spr...

This isn't just a stay; it's an invitation to the best of Spring Street. Whether you’re grabbing a coffee at Bad Bunnies or exploring the stores of Upper King, everything is within a few mins.' walk. After exploring, getaway to your gated...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 5
NEW! Close To Downtown Charleston And Be...

Come experience Charleston while staying in this ideally styled new build. 4 miles to Downtown Charleston with award winning eateries, amazing nighttime life, and historic beauty. Centrally located to Folly Beach and Sullivans Island Beach, both...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
2BR Spring Street Retreat - B

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 3 Bedrooms
  • 1 Bathrooms
  • Sleeps 6
4BR New - Close to Folly Beach!

Escape to this handsome 2025-constructed home on James Island, just 10 mins. from Folly Beach and 20 mins. from downtown Charleston. Featuring 4 roomy bedrooms, 3.5 bathrooms, an open-concept layout, completely equipped kitchen, garage access, ample...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Casa Zoë | Historic Garden Carriage Hou...

Summary:OP2026-07206A hidden gem in the heart of Charleston, Gibbon House is a charmingly restored brick carriage home with a story to tell. Once the office space for the Charleston Symphony Orchestra, it now offers chic, design-forward hospitality...

  • Charleston
  • 2 Bedrooms
  • 1 Bathrooms
  • Sleeps 4
Stylish Getaway in Downtown Charleston

Summary:Discover a guest-favorite getaway just steps from the best of Charleston. Ideal for couples, families, or modest groups seeking an elevated stay, it’s mins. from top eateries, stores, and landmarks, with painless access to galleries...

  • Charleston
  • 2 Bedrooms
  • 1 Bathrooms
  • Sleeps 5
Newly Renovated 4BR DT, Walkable!

Summary:Welcome to your Charleston escape, a impressive 4-bedroom getaway where timeless craftsmanship meets modern comfort. With gleaming pine floors, intricate moldings, and gorgeous design details throughout, this home offers the ideal blend of...

  • Charleston
  • 4 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
Soho House | Prime Location, Walk to Eve...

Summary:This home is ideal for couples, families or modest groups looking to appreciate walkability, appeal and painless access to the city’s best attractions while also having a peaceful space to relax.The Space:Feel the charm of historic...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Large 4bd Artists Home, Walk to King

Summary:Some homes make your trip memorable. The Big Palmetto is one of them. This roomy four-bedroom getaway invites you to slow down, gather with the people you appreciate, and experience Charleston from one of its most impressive historic...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Private Balcony • 2 Living Rooms • W...

Summary:Welcome to Azaleas on Spring – Suite B!???? Balcony overlooking historic Spring St???? 2.5 Blocks to King St – Walk to Charleston’s Finest Dining, Shopping & Nightlife????️ Bonus second Living Room???? Street Parking for 1 Car???...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Lovely 4BR/2BA Home! Less Than 10 Minute...

Our delightful 4 bedroom/2 bath home is ideally located in the heart of the beautiful James Island neighborhood. Drive 10 mins. to Downtown Charleston and 8 mins. to Folly Beach. The 1510 square foot single-level home has four bedrooms and two full...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 7
3 Bed 3 Bath Historic Home `4 Blocks fro...

Freshly-modernized three bedroom historic home in the trendy, laid-back Cannonborough neighborhood close to great eateries & historical sights.This classic Charleston home is made up of two units A&B, this is the listing for Unit B (upstairs unit)...

  • Charleston
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 6
Backyard Serenity, Balcony Views | Palme...

Permit Number: 06838The Space: Welcome to Palmetto House, a handsomely restored Charleston home where historic appeal meets modern comfort. With four inviting bedrooms and thoughtful gathering spaces throughout, this home is ideal for families or...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 9
Cozy 5BR/5BA Downtown House w. Pool & Pa...

Summary:Feel Charleston appeal in this newly modernized 5BR/5BA getaway just one block from King Street. Comfortably sleeps 11 with luxe king beds, modern open living spaces, and a completely equipped kitchen. Appreciate Intelligent TVs, high-speed...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Charming 3-BR Historic Charleston home n...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Newly Remodeled, Spacious Rental! Walk t...

Summary:Welcome to your charmingly restored downtown Charleston getaway, a classy two-story residence located within a historic building that has been thoughtfully transformed with modern luxury and timeless appeal. Featuring high-end finishes...

  • Charleston
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 9
Private Historic Residence | 5BR/3BA | S...

Summary:The Quartiers Charlestonian are a blend of historic appeal and modern luxury featuring five queen bedrooms and three baths, two private kitchens and laundry units in which were thoughtfully remodeled. These adjoining historic suites provide...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Blue Cottage | Casa Zoë – Your Charle...

Summary:OP2025-05857Blue Cottage is your private and intimate Casa Zoë sanctuary with history in its bones and style in its soul. Tucked on Charleston's most coveted block, this stand-alone bungalow offers the rare blend of total privacy and...

  • Charleston
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 5