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Isle of Palms, SC 4+ Bedroom Vacation Rentals

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201 rentals found
Golf Views, Private Pool, Screen Porch, ...

5 Bedroom, Private Pool, 12th Green on Harbor Course, Close to Isle of Palms Marina. $250 credit toward beach gear units with VayK Life (3-21 nights only). Ideal Family Getaway! Off season discounts and long-term units available until March 2025...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Gated Ocean Point Home, 4BR, End Unit, P...

Welcome to 30 Ocean Point Drive — your ideal coastal hideaway inside the peaceful, gated Ocean Point neighborhood of Wild Dunes Resort on the Isle of Palms. This handsome 4-bedroom, 4-bath corner lot home sits just steps from the beach and offers...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Award-Winning Resort Amenities | Beachwo...

Beachwood West 6 by Wild Dunes5 Bedrooms | 3.5 Bathrooms | Sleeps 12 | Resort View________________________________________Welcome to Beachwood West 6, a impressive getaway on Isle of Palms’ exclusive Wild Dunes Resort. Located in the exclusive...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
Award-Winning Resort Amenities | Fairway...

Fairway Oaks 19 by Wild Dunes4 Bedrooms | 3 Bathrooms | Sleeps 10 | Resort View________________________________________Fairway Oaks 19, a striking getaway on Isle of Palms’ exclusive Wild Dunes Resort. Where Lowcountry appeal meets modern comfort...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Fabulous Modern IOP Home! Pool and Hot T...

Escape to this impressive 5-bedroom, 4-bath beach vacation rental at 10 Wills Way on the Isle of Palms, just 20 mins. from historic Charleston. This property is new to the rental market and features all-new furnishings, offering modern comfort with...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Screen porch, Golf Cart, Pet friendly, L...

All new reservation (3-21 nights) will receive $250 credit toward beach gear units with VayK Life!Charming Island home with hot tub! Unwind in the living room with flat-screen TV, den, and 2 front verandas, all with ample seating. Totally supplied...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Stay @ White Sands on Isle of Palms

White SandsLocation: Isle of Palms, South CarolinaOverview:Welcome to White Sands, a elegantly modernized 4-bedroom, 4.5-bathroom coastal getaway on Palm Boulevard. Professionally designed with high-end finishes, this elegant home offers luxury...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
New Ocean View Home: Pool & Putting Gree...

Overview:Welcome to 6 49th Ave - Oak and Ocean! This brand new 5 bedroom; 5 ½ bath home was just finished in January 2026 and is ready for the first lucky guests. The décor is professionally designed with a sophisticated, yet comfortable vibe. The...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Pool, Beach Access, Walk to Town, Pet ok...

Make everlasting memories with you and your whole family on your next vacation at 808 Ocean Boulevard. 808 Ocean Boulevard is a impressive private 6 bedroom 6 bath home located oceanfront on the southern side of the Isle of Palms. Just mins. walk...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 14
New, Luxurious Coastal Gem! Private Pool...

Feel The Pinnacle of Coastal Luxury in this Renovated Home - 9 on 30th Ave!Property HighlightsChef's kitchen with premium appliancesPrivate saltwater pool & professional grillePutting green & fire pitRooftop deck with partial ocean vistas$250...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Gorgeous IOP Home, Second Row, Private P...

Welcome to your ideal beach hideaway! This impressive 4-bedroom vacation rental is located on the second row from the beach, offering painless beach access—just 50 yards away—and a partial ocean view through the trees and neighboring homes. It's...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Saltwater Sanctuary | Ocean Views + Priv...

The Delaney House – Relaxed Coastal Luxury on Isle of PalmsWelcome to The Delaney House, a attractively refreshed Isle of Palms getaway where ocean vistas, casual coastal interiors, and a private saltwater pool create the ideal backdrop for an...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Sea Shell by AvantStay | Breezy Beachsid...

Welcome to Sea Shell by AvantStay!Heaven beckons from this exceptional beach home that's located only 1 block away from the sandy shores of Isle of Palms Beach. After a day spent frolicking in the waves, strolling down the boardwalk, and...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Gorgeous Beach Home, Ocean Views, w/Priv...

Welcome to 811 Ocean Boulevard on Isle of Palms! – An Enchanting Coastal RetreatStep into a realm of comfort and appeal as you discover this charming five-bedroom, five-bathroom home located in the heart of Isle of Palms, a heaven for both...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
IOP Home, Ocean and Intracoastal Views! ...

Welcome to this fun beach hideaway on the southern end of the Isle of Palms, where relaxation meets Lowcountry living. Located just a short 3-min. walk from the ocean near Breach Inlet, this three-level haven with private pool, spectacular indoor ...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Ultimate IOP Vacation- 6BR with Pool & S...

Welcome to 2905 Palm Boulevard! Located on the charming ocean-side of the Isle of Palms, a classic beach town near historic Charleston, South Carolina, this gorgeous home was FULLY REBUILT IN 2024 and expanded to 6 roomy bedrooms - all with ensuite...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 14
7BR Coastal Retreat • Walk to Beach + ...

Just steps from Isle of Palms’ Front Beach scene, 6 10th Avenue puts big-group coastal living right where guests want to be—near the sand, surf, eateries, ice cream stores, and live music that make this Charleston-area beach town so simple to...

  • Isle of Palms
  • 7 Bedrooms
  • 5 Bathrooms
  • Sleeps 15
1blck to Beach, Pool, Outdoor Kitchen, G...

Welcome to Pelican, an AvantStay home!Just a block from the famed Island of Palms Beach, this striking, modern getaway is the ideal spot for your next coastal hideaway. An exceptional outdoor space presents a taste of heaven, where days are spent...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12