Charleston-SC.com logo

Charleston, SC 5+ Bedroom Vacation Rentals

Filter 5+ Bedroom Charleston Properties by: Company | Pet-Friendly | or choose different a Area or Bedrooms
No company options available.
Bedrooms:
162 rentals found
The Overlook on King

Summary:Located on King Street, Charleston’s most impressive and beautiful retail, entertainment, and dining corridor, The Overlook on King is one of Charleston’s newest and most extravagant properties. The highlight is a one-of-a-kind rooftop...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 11
New design & construction, 6 Bed, 6 EnSu...

Welcome to 183 Saint Philip Street, your chic haven in the heart of Charleston! This new construction offers a prime location, placing you steps away from the city's vibrant attractions & best eateries. Each bedroom features 55" Samsung TVs ...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
93.5 A&B - New listing! 6 Bedrooms Close...

The property located at 93.5 unit A & B The Manor is a gorgeous two-story new construction home providing all the amenities of home combined with chic furnishings and an extraordinary location.Unit A is the first-floor unit with an open concept...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Great for Large Groups | The Waltz

Permit Number: 05635The Space: Welcome to The Waltz, a roomy 2nd and 3rd floor getaway designed for gathering, calming, and making memories together, offering 5 bedrooms and 4 full bathrooms in a prime Spring Street location with complimentary...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Luxurious Waterfront Getaway, minutes fr...

This Waterfront, 5 Bedroom / 5 Bathroom home on Oak Island is 100% gut remodeled, mins. from Folly Beach and is the ideal hideaway for families and friends. All bedrooms have king size beds. The home features two kitchens both entirely equipped. ...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 8
Downtown Charleston Gem, Walk Everywhere...

Summary:Welcome to The Lavender & Sage Suites a charmingly restored 6BR 6.5BA home that pairs modern luxury with timeless Southern appeal. Located in the heart of downtown Charleston, you're just steps from the city's best eateries, nightlife, and...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
3 Blocks to King Street | 6 BR | Maison ...

Permit Number: 05740The Space: Stay in the heart of Charleston in this elegantly restored 1890s home just steps from King Street, offering six bedrooms and six and a half bathrooms across two private floors, ideal for sizable groups seeking comfort...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 13
Newly Built, Luxury, Private Rooftop + P...

Summary:Meet The Charlee on Cannon, a fresh take on luxury stays in the heart of downtown Charleston. This freshly constructed five-bedroom getaway was designed for effortless group getaways, featuring sun-filled living spaces, a chef's kitchen, and...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 11
Casa Zoë | Grand Sparrow House

Summary:OP2026-07255OP2026-07256OP2026-07257Casa Zoë’s crown jewel, The James Sparrow House, is a sizable Federal-style landmark reimagined for modern gatherings. Entirely redesigned, it blends 19th-century craftsmanship with bold interiors and...

  • Charleston
  • 9 Bedrooms
  • 7 Bathrooms
  • Sleeps 27
Luxury 6BR w/ Pool Downtown CHS

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
11 Bed Compound for Large Groups, Prime ...

Summary:Welcome to The Grandiose Estate, a private getaway in the heart of downtown Charleston, SC. Located within a meticulously restored historic home, this exclusive property features four completely furnished residences, creating the ideal...

  • Charleston
  • 11 Bedrooms
  • 8 Bathrooms
  • Sleeps 24
Rare French Quarter Escape, Sleeps 16 w....

Summary:Located in the heart of the French Quarter and draped in history, this private, secure 3,300 sq. ft. luxury getaway comfortably sleeps 16 guests with 5 cavernous bedrooms, dual master suites, ensuite bathrooms, and upgraded luxury amenities...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
Boho Rosa | Famous Pink House with Pool ...

Summary:Welcome to Boho Rosa, a vibrant getaway named one of Condé Nast Traveler’s Top 10 Airbnbs in Charleston three years in a row. Behind its iconic pink exterior, professionally designed boho-chic interiors blend with classic Southern appeal...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Guesthouse Charleston: WEST (242 B & C)

West 242 B and 242 C are two appealing standalone homes located in the heart of Charleston's vibrant Cannonborough/Elliotborough neighborhood, just two blocks from historic King Street. This prime location offers painless access to Charleston's best...

  • Charleston
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Private Pool! | Rooftop Patio | The Athe...

Permit Number: 07351The Space: Welcome to Athena — a cavernous 3-story downtown getaway constructed for gathering. With 5 bedrooms, 3.5 baths, a opulent private pool, and a bright open layout, this home is ideal for families and bigger groups who...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Historic Duplex 6 Blocks To King - Lots ...

Summary:Take it simple on the porch after a long day at the beach, then pull up a chair for a casual dinner. This beautiful duplex offers a touch of sophistication tucked into historic downtown Charleston.Think of everything you'd want for your...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
King St. Getaway - Renovated 6 Bedroom D...

Summary:Welcome to King St. Getaway, a elegantly refreshed six-bedroom home in downtown Charleston where modern upgrades meet generous space. Ideal for sizable groups or families looking to discover King Street by day and getaway into luxury by...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
The Cannon Exchange Building By Charlest...

Feel the pinnacle of Charleston living at the Cannon Exchange Building, a thoughtfully designed luxury property offering two broad residences: The Chateau and The Soirée. Each unit accommodates up to 14 guests, making the building ideal for huge...

  • Charleston
  • 10 Bedrooms
  • 10 Bathrooms
  • Sleeps 28