Charleston-SC.com logo

Charleston, SC 4+ Bedroom Vacation Rentals

Filter 4+ Bedroom Charleston Properties by: Company | Pet-Friendly | or choose different a Area or Bedrooms
No company options available.
Bedrooms:
365 rentals found
Chic Historic Victorian Duplex 2 Blocks ...

Summary:Stay at The Dunes on Spring, our gorgeously refreshed 1905 Charleston Victorian duplex home in the heart of Cannonborough. Just 2 blocks from King Street, this handsome property features nearly 2600 square feet of ideally designed space. The...

  • Charleston
  • 6 Bedrooms
  • 3 Bathrooms
  • Sleeps 13
Guesthouse Charleston: SOUTH (82 A)

82 - A is located on the first floor of a charming standalone home, offering a roomy four-bedroom, four-and-a-half-bathroom apartment ideal for a weekend hideaway. Step inside to find an inviting open living, dining, and kitchen area, ideal for...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
High-End New Build near Folly Beach and ...

Summary:Welcome to your coastal escape in James Island, SC! Industrial chic meets coastal farmhouse in this brand-new luxury home, centrally located just 10 mins. from Folly Beach and 10 mins. from historic downtown Charleston, offering the ideal...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 11
Classic Home - 5 Star Location - Histori...

Summary:Feel Charleston appeal in this 4BR, 3BA home in the heart of the Historic District. With a Walk Score of 98, you’re just blocks from the iconic City Market and steps to King Street’s top stores, eateries, and rooftops. The home features...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
*Newly Renovated!* Guesthouse Charleston...

Welcome to your home away from home in the heart of Charleston. This charmingly remodeled four-bedroom, four-and-a-half-bathroom residence is located on the first floor of a striking two-unit duplex on the highly charming Spring Street just steps...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Great Downtown Charleston Location!

Feel what it means to live like a local in our 2-story Downtown Charleston home. This home is 6 beds / 5.5 baths and would be ideal for enormous groups/families of up to 12 people. Located 1 block off King Street, you can walk to eateries, bakeries...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
 New Upscale 4 Bedroom, King Beds , Priv...

Your Charleston adventure begins at this enchanting 4-bedroom home.Stay Cannon is a legally allowed vacation rental as required by Charleston City Ordinance and is located in the fashionable Cannonborough/Elliotborough neighborhood.Great for family...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Cozy 5BR/5BA Downtown Gem - Close to Kin...

Summary:Feel Charleston appeal in this freshly refreshed 5BR/5BA getaway just one block from King Street. Comfortably sleeps 11 with luxe king beds, modern open living spaces, and a entirely equipped kitchen. Savor Intelligent TVs, high-speed WiFi...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Brand NEW! 5BR/5BA Home, Perfect for Gro...

26 Bee Street features two distinct units in Charleston's beautiful Cannonborough/Elliotborough neighborhood. This vibrant property includes five bedrooms and five bathrooms across both units, each elegantly restored to showcase historic appeal...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
Casa Zoë | Grand Sparrow House

Summary:OP2025-05862Casa Zoë’s crown jewel, The James Sparrow House, is a huge Federal-style landmark reimagined for modern gatherings. Entirely redesigned, it blends 19th-century craftsmanship with bold interiors and curated art. With 9...

  • Charleston
  • 9 Bedrooms
  • 7 Bathrooms
  • Sleeps 27
The Jessamine | 9BR Historic Downtown Ab...

Summary:Welcome to your Cannonborough hideaway, a freshly modernized 3-unit property just one block from iconic King Street. Ideal for families or groups of friends, this getaway blends comfort, style, and convenience. With refreshed interiors, a...

  • Charleston
  • 9 Bedrooms
  • 5 Bathrooms
  • Sleeps 16
Spring St - Downtown - Walk Everywhere!

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Cocktail Club | 4 Redesigned Suites

Permit Number: 05591The Space: Appreciate gracious Southern living in our cavernous 8 BR home. The home is divided into four charmingly designed 2 BR units, making this property ideal for enormous groups. Each unit has been thoughtfully decorated to...

  • Charleston
  • 8 Bedrooms
  • 4 Bathrooms
  • Sleeps 17
Luxury Retreat with 4 King Suites

Summary:Discover The Carolina Rose, a brand-new 4-bed, 4-bath luxury Charleston getaway constructed in 2023. Ideal for families or groups, this beautiful home comfortably sleeps 8+ and is just a 5-block walk from vibrant King Street. Appreciate...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 9
Downtown Duplex - St Philip St

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 16
Retreat Near the Charleston Greenway-Wat...

Cavernous and family-friendly getaway ideally located near the Charleston Greenway with peaceful tidal water vistas. This 4-bedroom, 2.5-bath home offers plenty of room for groups of all sizes, featuring three bedrooms with comfortable queen beds...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 9
Historic Charleston home located in the ...

Located in the heart of downtown Charleston, John Street offers the ideal blend of accessibility and tranquility. Within walking distance to all the top attractions in downtown, this home is tucked away in the peaceful Garden District, bordered by...

  • Charleston
  • 4 Bedrooms
  • 5 Bathrooms
  • Sleeps 8
4 Bedroom - 4 Blocks to King St. with Pa...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10