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Charleston, SC 4+ Bedroom Vacation Rentals

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350 rentals found
Historic Charleston home located in the ...

Located in the heart of downtown Charleston, John Street offers the ideal blend of accessibility and tranquility. Within walking distance to all the top attractions in downtown, this home is tucked away in the relaxing Garden District, bordered by...

  • Charleston
  • 4 Bedrooms
  • 5 Bathrooms
  • Sleeps 8
The Wilborn House | 5 Blocks from King S...
4.8
(6)

Permit Number: 05057,174The Space: This freshly remodeled and refurbished 4 bedroom,4 bathroom full home is divided into 2 separate units (one upstairs and one downstairs) and is ideal for sizable groups of friends or multiple families. With its...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
The Bogard Duo 6 Bed 6 Bath

Freshly-refreshed six bedroom historic home in the fashionable, laid-back Cannonborough neighborhood close to great eateries & historical sights.This classic Charleston home is made up of two units A&B, this is the listing for both units. The entire...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Poseidon | 3rd Floor Private Sundeck
4.9
(14)

Permit Number: 06282The Space: ???? Welcome to Poseidon - Your Charleston Retreat!Discover the luxury of our cavernous unit, ideal for huge groups or families, with 5 bedrooms and 3.5 full baths. Conveniently located right off Spring Street, savor...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Guesthouse Charleston: SOUTH (105.5)
4.9
(45)

South 105.5 is a gorgeously refreshed 4-bedroom, 4.5-bathroom bungalow located in the beautiful Cannonborough/Elliotborough neighborhood just steps from some of the city's best eateries, stores, and historic sights.Step inside to find an...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Guesthouse Charleston: SOUTH (82 A & B)
5.0
(4)

82 A & B is a cavernous two-story home, appealingly located within walking distance of Charleston's best eateries, bars, and attractions. Ideal for sizable groups, the home features two completely equipped kitchens, two living areas, and multiple...

  • Charleston
  • 8 Bedrooms
  • 9 Bathrooms
  • Sleeps 18
St. Philip | Luxury Home w/ Rooftop Pati...

Summary:Escape to luxury at our completely modernized getaway, just steps from King St. Revel in chic interiors flooded with natural light through wrap-around windows. This Charleston gem offers 4 bedrooms, 3.5 baths with rain showers, open living...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Southern Charms Duplex on Spring <> Slee...

Welcome to the Holy City, and the historic southern appeal of the Charleston peninsula. Our Vacation Rental By Owner is located in impressive downtown Charleston and just mins. away from MUSC, the College of Charleston, and King Street’s shopping...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 12
Vacation Villa 5 mins to King ‘The Pal...
5.0
(2)

Summary:Vacation Villa 5 min. walk to King St, in the heart of downtown Charleston. This tropical getaway offers sleek design, soaring 25’ ceilings, open first floor kitchen & living room, and cavernous bedrooms with en-suite spa bathrooms. The...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Royal Cottage II –  Light, Art, & Loca...

Summary:Royal Cottage II is a modern-meets-historic Casa Zoë sanctuary. Designed with soul, light, and intention. Featuring four thoughtfully appointed bedrooms (each with ensuite baths), vaulted ceilings, wood floors, and gallery-worthy art...

  • Charleston
  • 4 Bedrooms
  • 5 Bathrooms
  • Sleeps 8
1905 Victorian Historic Home Just 2 Bloc...
5.0
(22)

Summary:Stay at our impressive 1905 Charleston Victorian home in the heart of Cannonborough. Just 2 blocks from King Street, this property features nearly 1850 square feet of ideally designed space. The front home offers 4 full-sized bedrooms with...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
B2 at Saint Philip Square, One Block to ...
5.0
(26)

Welcome to Saint Philip Square, an award-winning collection of historic homes spanning nearly one city block of downtown Charleston. The Adams Bennett House at 174 B St. Philip St. Unit 2 is a 5 -BD 5- BA second floor gem blends modern comfort with...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Sandy Oaks: The Best of Both Worlds!

Beach? Downtown? Lowcountry experience? You don't have to compromise at Sandy Oaks! Bring your furry friend to savor the cavernous, completely fenced-in backyard, sip wine on the deck, and play foosball in the game room. Located 5 miles to Folly...

  • Charleston
  • 4 Bedrooms
  • 1 Bathrooms
  • Sleeps 8
Rustic Charleston Single with Rooftop De...
5.0
(14)

Location, location, location! This warm & welcoming six bedroom, 1852 Charleston single is just 2 blocks away from the Upper King St Shopping & Dining District. Recent renovations & preserved natural wood accents make for a comfortable stay to...

  • Charleston
  • 6 Bedrooms
  • 1 Bathrooms
  • Sleeps 14
Great Downtown Charleston Location!
5.0
(60)

Feel what it means to live like a local in our 2-story Downtown Charleston home. This home is 6 beds / 5.5 baths and would be ideal for huge groups/families of up to 12 people. Located 1 block off King Street, you can walk to eateries, bakeries...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
1 Block to King St | Plunge Pool | Sleep...

Summary:Feel luxury at The Pink Palm, a gorgeous new construction 4-bedroom, 4-bathroom getaway in downtown Charleston finished in APR 2025. Appreciate roomy living areas, elegant baths, and a completely equipped kitchen. Unwind in the private...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
The Elliotborough Suite | Prime 4BR Near...
4.9
(68)

Summary:Sensational 4 Bedroom/4.5 Bath Home in the Heart of Downtown!- 4 Master Bedrooms w/ En-Suite Bathrooms, + pullout couch bed available- 2 Blocks from the iconic King Street- Off-Street Parking Supplied - Walk to Everything!YOURPAD Charleston...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Luxurious 4BR Downtown Home - Walkable!

Summary:Welcome to "Luxurious 4BR Downtown Home - Walkable!", your ideal Charleston getaway! Located just off King Street in the Crosstown neighborhood, this gorgeous home offers 4 elegantly appointed bedrooms, each with a private en suite bath...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 9