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Charleston, SC 4+ Bedroom Vacation Rentals

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364 rentals found
Charleston Extended Stay w/ Yard!

2,100 Sq Ft | 10 Mi to DowntownThis beautiful Charleston vacation rental offers the ideal destination for a family getaway! Located 17 miles from Folly Beach, this home lets you appreciate the sun and sand before heading back to relax in front of...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
The Cannon Exchange Building By Charlest...

Feel the pinnacle of Charleston living at the Cannon Exchange Building, a thoughtfully designed luxury property offering two broad residences: The Chateau and The Soirée. Each unit accommodates up to 14 guests, making the building ideal for huge...

  • Charleston
  • 10 Bedrooms
  • 10 Bathrooms
  • Sleeps 28
Newly Built, Spacious, Luxury w. Bikes +...

Summary:Welcome to The Charlee on Cannon, an elevated getaway in the heart of downtown Charleston. This attractively designed five-bedroom residence features broad living spaces, a chef-inspired kitchen, and a private rooftop terrace ideal for...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Belle Haven Duplex - Downtown - New Reno...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Signature Residence @ Smalls Alley | Roo...

Welcome to the Signature Residence, a completely detached luxury home tucked inside Smalls Alley, a private enclave of standalone residences hidden just off the main streets of downtown Charleston. Steps from the city's best eateries and historic...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
B2 at Saint Philip Square, One Block to ...

Welcome to Saint Philip Square, an award-winning collection of historic homes spanning nearly one city block of downtown Charleston. The Adams Bennett House at 174 B St. Philip St. Unit 2 is a 4 -BD 5- BA second floor gem blends modern comfort with...

  • Charleston
  • 4 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
The Conroy | Perfect Location | Historic...

Permit Number: BL049129-09-2026The Space: Welcome to The Conroy, a remarkable historic building located along iconic Broad Street in the heart of downtown Charleston. Originally constructed around 1794, this charmingly preserved property offers a...

  • Charleston
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 15
Luxury Downtown Rental, 5 Beds, 3 Baths,...

Summary:Feel modern luxury in historic Charleston at The Charlee! This brand-new 4-bed, 3-bath home is steps from King Street's vibrant energy. Ideal for groups, it features a chef's kitchen, private balcony, and backyard space with a grille...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Edisto & Cooper House | Sleeps 14 | Full...

Summary:Book the whole home and bring everybody! Both floors are yours, with room for fourteen, an simple fit for bachelorette weekends, big birthdays, or the reunion that's been a long time coming. It's two full units, so between two kitchens and...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Harleston House, Sleeps 16,  Whole House...

Summary:Welcome to Harleston House in The Preserve. This premier property is one of our five sophisticated luxury homes located in the heart of downtown Charleston. With 7 elegantly designed bedrooms, each accompanied by a private bath, this...

  • Charleston
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 16
High Society | Historic District Gem Nea...

Summary:Feel High Society in this chic 6-bedroom, 3-bath home in Charleston’s Historic District. Unwind on private balconies with city vistas and savor the rare perk of off-street parking for four. Just blocks from King Street and the Charleston...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Lovely 4BR/2BA Home! Less Than 10 Minute...

Our enchanting 4 bedroom/2 bath home is ideally located in the heart of the charming James Island neighborhood. Drive 10 mins. to Downtown Charleston and 8 mins. to Folly Beach. The 1510 square foot single-level home has four bedrooms and two full...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 7
Classic Charleston Home, Steps to King, ...

Summary:Feel Charleston in this appealing two story, 5 Bedroom + 6 Full Bathroom Home! A classic Charleston Single on Coming Street, steps from famed King Street. Savor simple access to local bakeries, coffee stores, top-notch eateries and bars...

  • Charleston
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Bee & Blossom | Large Bed & Breakfast Bu...

Summary:Welcome to Bee & Blossom, a attractively restored 1910 Queen Anne Victorian home in Charleston’s historic Radcliffeborough neighborhood. Originally constructed in the early 20th century, the home blends historic Charleston character with...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Casa Zoë | Royal Cottage I – Designer...

Summary:OP2025-06816Royal Cottage I is a design-rich Casa Zoë getaway, combining classic Charleston appeal with gallery-style interiors and thoughtful details throughout. Featuring four bedrooms and five baths, vaulted ceilings, Slim...

  • Charleston
  • 4 Bedrooms
  • 5 Bathrooms
  • Sleeps 8
EAST 44 - Entire Home, Only 1 Block to K...

East 44 is a attractively restored historic home located in the vibrant Cannonborough/Elliotborough neighborhood. Just steps away, you'll find local favorites like Chubby Fish and Island Provisions, striking stores such as The Tiny Tassel and...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Charleston Style Full Duplex - 2 Blocks ...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 16
Newly Renovated 4BR 2BA Walk to King Str...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10