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Charleston, SC 4+ Bedroom Vacation Rentals

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356 rentals found
Historic Boutique Home ‘Tuckertown’

Summary:A short walk from King St. 'The Tuckertown' is a cavernous private historic property. The property offers an open kitchen & living area, opening directly to a traditional southern piazza. Plenty of space for guests to relax. Property...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Downtown Charleston - 4 Bedrooms / 2 Bat...

Summary:Step into this bright 4 bedroom, 2 bathroom home ideally suited for families or groups who adore space, style, and convenience. Located in downtown Charleston, this home offers an effortless mix of historic appeal and modern living. Just...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Backyard Serenity, Balcony Views | Palme...

Permit Number: 06838The Space: Welcome to Palmetto House, a gorgeously restored Charleston home where historic appeal meets modern comfort. With four inviting bedrooms and thoughtful gathering spaces throughout, this home is ideal for families or...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 9
Luxe Retreat | Near DT & Beaches | 4 BR,...

Summary:Welcome to Southern Shore! Unwind in this bright and modern NEW CONSTRUCTION home on James Island ideal for up to 10 guests. Savor an open layout, cavernous kitchen, 4 comfortable bedrooms, and complimentary beach gear. Unwind in the...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Third Floor Private Sundeck! | The Posei...

Permit Number: 06282The Space: Welcome to The Poseidon — a roomy downtown getaway just off Spring Street. With 5 bedrooms, 3.5 baths, and an open layout constructed for gathering, it’s an ideal setup for families and bigger groups.Cozy. Central...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Casa Zoë | Royal Cottage I – Designer...

Summary:OP2025-06816Royal Cottage I is a design-rich Casa Zoë getaway, combining classic Charleston appeal with gallery-style interiors and thoughtful details throughout. Featuring four bedrooms and five baths, vaulted ceilings, Slim...

  • Charleston
  • 4 Bedrooms
  • 5 Bathrooms
  • Sleeps 8
Charleston Family Getaway-A Charleston A...

RENOVATED, ROOMY & READY! This roomy 3238 square ft, upgraded home is a marvelous value for your family beach vacation, golf trip, or wedding season get together with friends!! No matter the occasion, this home will surely host you and your group...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 18
Six on Cannon | 6BR Charleston Home + Pa...

Summary:Welcome to Six on Cannon, a cavernous 6 bedroom 2 bathroom home ideally suited for families, friends, or get-togethers who want room, style, and downtown convenience together. Recently furnished and thoughtfully arranged, it gives you all...

  • Charleston
  • 6 Bedrooms
  • 2 Bathrooms
  • Sleeps 16
Charleston Luxury | Local Design 4BR w/ ...

Summary:Welcome to this attractively curated 4 bedroom getaway where local design touches meet modern comfort. Ideal for families, modest groups or creative travelers who want style, ease and a spot close to the best of Charleston. You get the...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
The Elliotborough Suite | Prime 4BR Near...

Summary:Welcome to your Charleston luxury stay where privacy, elegance and convenience converge. This four-master home is ideal for groups or families who savor fresh design and want independent space for everybody. You will appreciate generous en...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Charming 4-bedroom home, 10 Minutes to D...

Totally refreshed in 2025 -- Stay comfortably in Charleston at this 4-bedroom home. Each bedroom features a king bed, ensuring a pleasant nighttime's sleep for all guests. With amenities like a washing machine, WiFi, and AC, your stay will be both...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Casa Zoë: Bright Charleston Cottage Nea...

Summary:OP2026-07256OP2026-07257Point of View Cottage is a bright and airy Casa Zoë getaway made from two seamlessly connected spaces - ideal for families, friends, or groups who want to stay together but still savor a bit of breathing room. With...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
The Soiree by Charleston Vacays-New Buil...

Feel the epitome of modern Charleston living in this striking 5-bedroom, 5-bathroom vacation rental, aptly named The Soiree. Located in the heart of downtown Charleston, this extravagant abode offers an unbeatable location. Upper King Street, just a...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
4 Bedroom - 2 Blocks to King Street with...

Feel the timeless appeal of Charleston’s historic peninsula, the Holy City. Stay just mins. from MUSC, the College of Charleston, and the vibrant shopping, dining, and nightlife of King Street. From this ideally located downtown home, you’ll be...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
The King Suites at 493 - 8 Suites, 16 Be...

Permit Number: 004141The Space: Welcome to 493 Luxury Suites! These handsomely appointed units are found on the second floor of a historic building on King Street (above Sewing Down South, as seen on “Southern Charm”).Step into the building...

  • Charleston
  • 16 Bedrooms
  • 16 Bathrooms
  • Sleeps 52
Renovated 4bd Prime Location, Victorian ...

Summary:Discover your Charleston escape at this feature of The Heirloom collection, a elegantly restored 4-bedroom, 4-bath Victorian haven on historic Spring Street. Sleeping up to 10 guests with two cavernous living areas and sleeper couches, this...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Crosstown @ King | Elegant & Modern 6BR ...

Summary:Feel Charleston in style at this 6BR, 4BA Crosstown getaway just one block from King Street. Designed for up to 14 guests, the home combines modern finishes with cavernous comfort. Savor multiple living areas, a entirely equipped kitchen...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Guesthouse Charleston: SOUTH (105 ALL)

This combined listing for South 105 A, B, & 105.5 is a great space for enormous groups. Each unit has 4 bedrooms, and 4.5 bathrooms totalling 12 bedrooms, 12 full bathrooms, 3 half bathrooms, 3 full kitchen/living areas. Located on the desired...

  • Charleston
  • 12 Bedrooms
  • 13 Bathrooms
  • Sleeps 28