Charleston-SC.com logo

Charleston, SC 4+ Bedroom Vacation Rentals

Filter 4+ Bedroom Charleston Properties by: Company | or choose different a Area or Bedrooms
No company options available.
Bedrooms:
346 rentals found
Vacation Villa (ADA) 'The Mediterranean ...

Summary:Vacation Villa 5 min. walk to King St, in the heart of downtown Charleston. This tropical getaway offers sleek design, open first floor kitchen & living room, & cavernous bedrooms with en-suite spa bathrooms. Unwind in luxury at...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
The Lookout- hot tub, heated pool, with ...

Welcome to life in the Lowcountry at The Lookout! The design of this home embodies the natural beauty of life on the water with comfort and style. Heated pool just installed! Great place to cool off year round- close to the outdoor TV...

  • Charleston
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
The Inns | Grand 9BR Charleston Downtown...

Summary:Welcome to your Charleston gathering place where space meets luxury. This grandiose 9 bedroom home is constructed for sizable groups, offering eight full bathrooms to make everybody’s stay comfortable and convenient. Ideal for family...

  • Charleston
  • 9 Bedrooms
  • 8 Bathrooms
  • Sleeps 16
The Perfect Family Escape at The Barbuda

Permit Number: 06409The Space: ???? Welcome to Barbuda House! ???? Step into a world of luxury within this elegantly remodeled historic gem, encompassing the appeal of a traditional Charleston home originally constructed in the 1880's.As you enter...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
LOCATION! Stunning Downtown Home Steps t...

Summary:Welcome to The Pink Lotus, a beautiful 4-bedroom, 4-bathroom duplex located in the heart of downtown Charleston. This elegant and roomy home offers a ideal blend of modern amenities and historic appeal. With its prime location, you'll have...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
The Gardenia House | Unit B | Sleeps 9

Summary:Welcome to the Gardenia House in the Preserve, a refined luxury suite in downtown Charleston featuring 4 cavernous bedrooms and 4 full baths. Designed for flexibility and comfort, this gorgeous suite can be rented separately or combined with...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 9
The Cavallo- Private Rooftop Deck & Pool

Entire New 3 Story House w/ Private Heated Spa/Pool, Roof Top Deck & Elevator. Brand new home in historic Charleston with private jetted heatable spa/pool and rooftop deck. Located just one block from Upper King Street within the...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
The Inns | Luxury Design w. Speakeasy Ba...

Summary:Surrounded by swaying Spanish moss in one of Charleston’s most photogenic neighborhoods, this striking 7-bedroom, 5-bath home captures the essence of Southern grace with a modern twist. Thoughtfully refreshed in September 2025, every...

  • Charleston
  • 7 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Harleston Village | Stylish & Spacious H...

Summary:Charming Historic Retreat in the Heart of Charleston! This 3-bedroom, 2.5-bath home is located in the highly sought-after Harleston Village, just a short walk from some of Charleston’s most beloved spots. Savor painless access to Cannon...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 7
The Historic St. Philip House - One Bloc...

**Daniel and I wanted to inform you of a new construction project that has newly started on the lot adjacent to our home. The construction will be active Monday-Friday and possibly on Saturday's. The starting time during the week is possibly as...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
The Globetrotter | A Locals Hotspot

Permit Number: 05139,40The Space: Our cavernous 1st & 2nd floor home, ‘The Globetrotter House’, is ideal for groups of 8-11 guests with 4 bedrooms, and 4 full baths. Located just off Spring Street, location and parking won't be an issue...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 9
THE DELPHINE Luxury Downtown Charleston ...

Welcome to your chic getaway in the heart of Downtown Charleston! Located in the striking Cannonborough/Elliotborough District, this handsome home constructed in 2022 is just steps from King Street’s top eateries, stores, and nightlife. Savor...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
? Walk Score 98 ? 1blk to King St. Outdo...

Summary:Welcome to your Charleston gathering spot, a cavernous 6-bedroom home constructed for enormous groups seeking style, flexibility, and unbeatable walkability. Featuring two high end kitchens, generous living spaces, and just one block from...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 16
Downtown Charleston - 4BR Luxurious Geta...

Summary:Discover this 4BR/4BA Charleston hideaway, ideally located just off King Street in the Crosstown neighborhood. Each bedroom offers a private en suite, with modern design, Intelligent TVs, and high-speed WiFi throughout. Savor a completely...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 9
New! The Palmetto House- 3 Blocks To Kin...

Summary:Feel the ideal fusion of history and modern luxury at The Palmetto House, This remarkable 4-bedroom, 3-bath second-floor apartment is located within a historic Charleston home. This impressive getaway is your gateway to Charleston, located...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Charming 4-bedroom home, 10 Minutes to D...

Totally refreshed in 2025 -- Stay comfortably in Charleston at this 4-bedroom home. Each bedroom features a king bed, ensuring a pleasant nighttime's sleep for all guests. With amenities like a washing machine, WiFi, and AC, your stay will be both...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Lowcountry Family Getaway-A Charleston A...

RENOVATED, ROOMY & READY! This roomy 3238 square ft, upgraded home is a marvelous value for your family beach vacation, gentlemen's golf trip, or wedding season get together with friends!! No matter the occasion, this home will surely host you and...

  • Charleston
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 18
The Lord Ashley - Sleeps 8!

Our sun-filled home features an inviting open floor plan that includes two sitting rooms and a sizable dining area with bar that leads into the cavernous chef's kitchen. The completely equipped kitchen is complete with stainless steel appliances...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 8