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Charleston, SC 4+ Bedroom Vacation Rentals

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354 rentals found
Six on Cannon | 6BR Charleston Home + Pa...

Summary:Welcome to Six on Cannon, a roomy 6 bedroom 2 bathroom home ideally suited for families, friends, or get-togethers who want room, style, and downtown convenience together. Freshly furnished and thoughtfully arranged, it gives you all the...

  • Charleston
  • 6 Bedrooms
  • 2 Bathrooms
  • Sleeps 16
Only 1 Block to King! | The Sweetgrass

Permit Number: 06474The Space: Welcome to The Sweetgrass House, a cavernous two level getaway designed for groups of 8–10 guests looking for comfort, privacy, and an simple downtown Charleston stay. With four bedrooms and four full bathrooms, this...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Charleston Abode | Downtown, 1 Block fro...

Summary:Welcome to Charleston Abode, a luminous 2-bedroom getaway just one block from King Street where historic appeal meets modern comfort. Designed for couples or modest groups, this home offers airy interiors, fresh details, and rare outdoor...

  • Charleston
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
The Inns | Luxury Design w. Speakeasy Ba...

Summary:Surrounded by swaying Spanish moss in one of Charleston’s most striking neighborhoods, this impressive 7-bedroom, 5-bath home captures the essence of Southern grace with a modern twist. Thoughtfully modernized in September 2025, every...

  • Charleston
  • 7 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Guesthouse Charleston: WEST (62)

At 62 West, you'll feel right at home during your Charleston visit—front porch included! In addition to comfortable beds, this home offers a cavernous open-concept living room and kitchen, ideal for entertaining. The handsomely landscaped outdoor...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
The Cocktail Soiree | 4 Bedrooms | King ...

Permit Number: 05769The Space: Welcome to your ultimate King Street hideaway! ????✨This one-of-a-kind property features four private apartments spread across two floors — each with its own entrance, queen-sized bed, private full bathroom, and...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 8
Entire Home Rental in Downtown Charlesto...

Summary:Ideal for a huge family! This home is divided into two apartments, A & B, and this listing is for the entire home. This home sleeps 16 guests total. Just three blocks away from upper King Street. Our phenomenal cultural city also offers...

  • Charleston
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 16
Downtown Historic Home Steps to King St

Summary:Welcome to this impressive Southern bungalow, where classic elegance meets modern comfort. This enchanting home features four cavernous bedrooms and two elegantly appointed bathrooms, ideal for family living or entertaining guests. The...

  • Charleston
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 12
Modernized 5BR Family Home?Tranquil Pati...

This gorgeous 5-bedroom, 2.5-bathroom home is a true gem, located on one of the quietest streets in Charleston. With freshly refreshed bathrooms, resurfaced floors, and a roomy, open floor plan, this home is ideal for families or professionals...

  • Charleston
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
A Locals Hotspot! | The Globetrotter

Permit Number: 05139The Space: Welcome to The Globetrotter House — a cavernous, centrally located getaway just off Spring Street. With 4 bedrooms, 4 full baths, flexible sleeping options, and off-street parking, it’s an ideal setup for groups of...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 9
The Madison- Historic Charleston Single ...

Encompass yourself in the history of Charleston by staying in this freshly modernized 1890`s single home. This entire two story home offers guests all the aesthetic features of a Charleston Single House from its enormous double piazzas with blue...

  • Charleston
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 13
The Gardenia House | Sleeps 20 | Multi-U...

Summary:Welcome to the Gardenia House in the Preserve, a distinguished luxury residence located in the heart of downtown Charleston. This handsome property offers two exclusive suites within a cavernous layout of 7 bedrooms and 7 full baths, making...

  • Charleston
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 20
The Quad at 493 - 4 Suites - Right on Ki...

Permit Number: 004141The Space: Welcome to 493 Luxury Suites! These gorgeously appointed units are found on the second floor of a historic building on King Street (above Sewing Down South, as seen on “Southern Charm”).Step into the building...

  • Charleston
  • 8 Bedrooms
  • 8 Bathrooms
  • Sleeps 24
*Newly Renovated!* Guesthouse Charleston...

Welcome to your home away from home in the heart of Charleston. This handsomely refreshed four-bedroom, four-and-a-half-bathroom residence is located on the first floor of a appealing two-unit duplex on the highly beautiful Spring Street just steps...

  • Charleston
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Waterfront Escape - Private Pool, Dock, ...

Welcome to your ultimate waterfront escape just mins. from Folly Beach and the appeal of downtown Charleston. This cavernous home offers an memorable setting for family vacations, group getaways, or special events. Appreciate gorgeous water vistas...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Luxe 5BR w/ Heated Pool~1 Block to King~...

Welcome to The Lowcountry House, a delightfully restored 5-bedroom luxury getaway in the heart of Downtown Charleston with a Private Heated Pool. Originally constructed in the 1860s, this home exudes Lowcountry appeal with handcrafted details and...

  • Charleston
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Classic Charleston Home, Steps to King, ...

Summary:Feel Charleston in this striking two story, 5 Bedroom + 6 Full Bathroom Home! A classic Charleston Single on Coming Street, steps from famed King Street. Appreciate simple access to local bakeries, coffee stores, top-notch eateries and bars...

  • Charleston
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Walk Score 98 - 1blk to King St. Outdoor...

Summary:Welcome to your Charleston gathering spot, a cavernous 6-bedroom home constructed for sizable groups seeking style, flexibility, and unbeatable walkability. Featuring two high end kitchens, generous living spaces, and just one block from...

  • Charleston
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 16